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prfC protein (Nitrosomonas eutropha) - STRING interaction network
"prfC" - Peptide chain release factor 3 in Nitrosomonas eutropha
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
prfCPeptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (535 aa)    
Predicted Functional Partners:
Neut_2440
PFAM- binding-protein-dependent transport systems inner membrane component; KEGG- neu-NE2479 oligopeptide ABC transporter (497 aa)
              0.854
Neut_2441
Oligopeptide/dipeptide ABC transporter, ATPase subunit; KEGG- neu-NE2480 ATPase component ABC-type dipeptide/oligopeptide/nickel transport system; TIGRFAM- oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM- ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART- AAA ATPase; Belongs to the ABC transporter superfamily (685 aa)
              0.850
rpsB
PFAM- ribosomal protein S2; KEGG- neu-NE1718 ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family (251 aa)
     
 
  0.679
rplL
50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation (121 aa)
     
 
  0.675
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3’-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (217 aa)
     
 
  0.674
rplV
50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) (110 aa)
     
 
  0.670
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (208 aa)
   
      0.669
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (144 aa)
   
      0.665
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (129 aa)
   
 
  0.661
rpsC
30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (215 aa)
     
 
  0.660
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
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