node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Swol_1779 | fhs | Swol_1779 | Swol_1409 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.475 |
Swol_1779 | glyA | Swol_1779 | Swol_2392 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Ribose-5-phosphate isomerase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.820 |
Swol_1779 | guaB | Swol_1779 | Swol_0916 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.898 |
Swol_1779 | purC | Swol_1779 | Swol_1209 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: dsy:DSY0789 hypothetical protein; Belongs to the SAICAR synthetase family. | 0.997 |
Swol_1779 | purD | Swol_1779 | Swol_1774 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: gka:GK0268 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.975 |
Swol_1779 | purE | Swol_1779 | Swol_1780 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.985 |
Swol_1779 | purF | Swol_1779 | Swol_1778 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.986 |
Swol_1779 | purH | Swol_1779 | Swol_1775 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: mta:Moth_2044 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.997 |
Swol_1779 | purM | Swol_1779 | Swol_1777 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: dsy:DSY3929 hypothetical protein. | 0.929 |
Swol_1779 | purN | Swol_1779 | Swol_1776 | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.931 |
fhs | Swol_1779 | Swol_1409 | Swol_1779 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.475 |
fhs | glyA | Swol_1409 | Swol_2392 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Ribose-5-phosphate isomerase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
fhs | guaB | Swol_1409 | Swol_0916 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.437 |
fhs | purC | Swol_1409 | Swol_1209 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: dsy:DSY0789 hypothetical protein; Belongs to the SAICAR synthetase family. | 0.792 |
fhs | purD | Swol_1409 | Swol_1774 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: gka:GK0268 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.608 |
fhs | purE | Swol_1409 | Swol_1780 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.592 |
fhs | purF | Swol_1409 | Swol_1778 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.733 |
fhs | purH | Swol_1409 | Swol_1775 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: mta:Moth_2044 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.982 |
fhs | purN | Swol_1409 | Swol_1776 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
glyA | Swol_1779 | Swol_2392 | Swol_1779 | Ribose-5-phosphate isomerase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: mta:Moth_2052 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.820 |