node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfum_0043 | ligA | Sfum_0043 | Sfum_1428 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.405 |
Sfum_0043 | polA | Sfum_0043 | Sfum_1612 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.500 |
Sfum_0043 | ruvB | Sfum_0043 | Sfum_0993 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.615 |
Sfum_0996 | ruvA | Sfum_0996 | Sfum_0994 | PFAM: protein of unknown function DUF28; KEGG: sat:SYN_02974 hypothetical cytosolic protein. | Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.864 |
Sfum_0996 | ruvB | Sfum_0996 | Sfum_0993 | PFAM: protein of unknown function DUF28; KEGG: sat:SYN_02974 hypothetical cytosolic protein. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.607 |
Sfum_0996 | ruvC | Sfum_0996 | Sfum_0995 | PFAM: protein of unknown function DUF28; KEGG: sat:SYN_02974 hypothetical cytosolic protein. | Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.883 |
Sfum_1598 | ligA | Sfum_1598 | Sfum_1428 | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.421 |
Sfum_1598 | mfd | Sfum_1598 | Sfum_3479 | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.675 |
Sfum_1598 | polA | Sfum_1598 | Sfum_1612 | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.559 |
Sfum_1598 | ruvA | Sfum_1598 | Sfum_0994 | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.585 |
Sfum_1598 | ruvB | Sfum_1598 | Sfum_0993 | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.635 |
Sfum_1598 | ruvC | Sfum_1598 | Sfum_0995 | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.444 |
clpB | ruvB | Sfum_0263 | Sfum_0993 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.583 |
ligA | Sfum_0043 | Sfum_1428 | Sfum_0043 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.405 |
ligA | Sfum_1598 | Sfum_1428 | Sfum_1598 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | 0.421 |
ligA | polA | Sfum_1428 | Sfum_1612 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.777 |
ligA | ruvA | Sfum_1428 | Sfum_0994 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.506 |
ligA | ruvB | Sfum_1428 | Sfum_0993 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.690 |
mfd | Sfum_1598 | Sfum_3479 | Sfum_1598 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: gme:Gmet_0367 cell divisionFtsK/SpoIIIE. | 0.675 |
mfd | polA | Sfum_3479 | Sfum_1612 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.591 |