node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfum_0043 | Sfum_0261 | Sfum_0043 | Sfum_0261 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | 0.733 |
Sfum_0043 | Sfum_0343 | Sfum_0043 | Sfum_0343 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | KEGG: mca:MCA1306 DnaK-related protein. | 0.962 |
Sfum_0043 | clpP | Sfum_0043 | Sfum_0100 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.967 |
Sfum_0043 | dnaK | Sfum_0043 | Sfum_0260 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.963 |
Sfum_0043 | dnaK-2 | Sfum_0043 | Sfum_1036 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.963 |
Sfum_0043 | groL1 | Sfum_0043 | Sfum_0121 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.597 |
Sfum_0043 | groL2 | Sfum_0043 | Sfum_2345 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.597 |
Sfum_0043 | grpE | Sfum_0043 | Sfum_1035 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.881 |
Sfum_0043 | hrcA | Sfum_0043 | Sfum_1034 | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.747 |
Sfum_0261 | Sfum_0043 | Sfum_0261 | Sfum_0043 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.733 |
Sfum_0261 | Sfum_0343 | Sfum_0261 | Sfum_0343 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | KEGG: mca:MCA1306 DnaK-related protein. | 0.905 |
Sfum_0261 | clpB | Sfum_0261 | Sfum_0263 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.882 |
Sfum_0261 | clpP | Sfum_0261 | Sfum_0100 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.508 |
Sfum_0261 | dnaK | Sfum_0261 | Sfum_0260 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.989 |
Sfum_0261 | dnaK-2 | Sfum_0261 | Sfum_1036 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.980 |
Sfum_0261 | groL1 | Sfum_0261 | Sfum_0121 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.657 |
Sfum_0261 | groL2 | Sfum_0261 | Sfum_2345 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.657 |
Sfum_0261 | grpE | Sfum_0261 | Sfum_1035 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.955 |
Sfum_0261 | hrcA | Sfum_0261 | Sfum_1034 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: noc:Noc_1382 heat shock protein DnaJ-like. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.726 |
Sfum_0343 | Sfum_0043 | Sfum_0343 | Sfum_0043 | KEGG: mca:MCA1306 DnaK-related protein. | KEGG: dde:Dde_2099 ATPase; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.962 |