node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfum_0150 | Sfum_0166 | Sfum_0150 | Sfum_0166 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | RNA modification enzyme, MiaB family; KEGG: sat:SYN_00797 tRNA 2-methylthioadenosine synthase -like protein; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB. | 0.630 |
Sfum_0150 | fmt | Sfum_0150 | Sfum_0148 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.999 |
Sfum_0150 | miaB | Sfum_0150 | Sfum_0419 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | tRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.630 |
Sfum_0150 | rimO | Sfum_0150 | Sfum_1585 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | MiaB-like tRNA modifying enzyme YliG; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. | 0.630 |
Sfum_0150 | rlmN | Sfum_0150 | Sfum_4057 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Radical SAM domain protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.964 |
Sfum_0166 | Sfum_0150 | Sfum_0166 | Sfum_0150 | RNA modification enzyme, MiaB family; KEGG: sat:SYN_00797 tRNA 2-methylthioadenosine synthase -like protein; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.630 |
Sfum_0166 | Sfum_1360 | Sfum_0166 | Sfum_1360 | RNA modification enzyme, MiaB family; KEGG: sat:SYN_00797 tRNA 2-methylthioadenosine synthase -like protein; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB. | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.605 |
Sfum_0166 | rlmN | Sfum_0166 | Sfum_4057 | RNA modification enzyme, MiaB family; KEGG: sat:SYN_00797 tRNA 2-methylthioadenosine synthase -like protein; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB. | Radical SAM domain protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.666 |
Sfum_1360 | Sfum_0166 | Sfum_1360 | Sfum_0166 | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | RNA modification enzyme, MiaB family; KEGG: sat:SYN_00797 tRNA 2-methylthioadenosine synthase -like protein; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB. | 0.605 |
Sfum_1360 | miaB | Sfum_1360 | Sfum_0419 | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | tRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.614 |
Sfum_1360 | rimO | Sfum_1360 | Sfum_1585 | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | MiaB-like tRNA modifying enzyme YliG; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. | 0.489 |
Sfum_1360 | rlmN | Sfum_1360 | Sfum_4057 | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Radical SAM domain protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.633 |
Sfum_4054 | Sfum_4058 | Sfum_4054 | Sfum_4058 | PFAM: TPR repeat-containing protein; Sporulation domain protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: sat:SYN_01414 tetratricopeptide repeat family protein. | PFAM: histone deacetylase superfamily; KEGG: sat:SYN_02870 histone deacetylase domain protein. | 0.587 |
Sfum_4054 | hisG | Sfum_4054 | Sfum_4055 | PFAM: TPR repeat-containing protein; Sporulation domain protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: sat:SYN_01414 tetratricopeptide repeat family protein. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.790 |
Sfum_4054 | hisI | Sfum_4054 | Sfum_4056 | PFAM: TPR repeat-containing protein; Sporulation domain protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: sat:SYN_01414 tetratricopeptide repeat family protein. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.806 |
Sfum_4054 | rlmN | Sfum_4054 | Sfum_4057 | PFAM: TPR repeat-containing protein; Sporulation domain protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: sat:SYN_01414 tetratricopeptide repeat family protein. | Radical SAM domain protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.652 |
Sfum_4058 | Sfum_4054 | Sfum_4058 | Sfum_4054 | PFAM: histone deacetylase superfamily; KEGG: sat:SYN_02870 histone deacetylase domain protein. | PFAM: TPR repeat-containing protein; Sporulation domain protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: sat:SYN_01414 tetratricopeptide repeat family protein. | 0.587 |
Sfum_4058 | hisG | Sfum_4058 | Sfum_4055 | PFAM: histone deacetylase superfamily; KEGG: sat:SYN_02870 histone deacetylase domain protein. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.595 |
Sfum_4058 | hisI | Sfum_4058 | Sfum_4056 | PFAM: histone deacetylase superfamily; KEGG: sat:SYN_02870 histone deacetylase domain protein. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.595 |
Sfum_4058 | rlmN | Sfum_4058 | Sfum_4057 | PFAM: histone deacetylase superfamily; KEGG: sat:SYN_02870 histone deacetylase domain protein. | Radical SAM domain protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.777 |