STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UREG_074003-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (446 aa)    
Predicted Functional Partners:
UREG_01707
3-hydroxy-3-methylglutaryl coenzyme A reductase.
  
 
 0.998
UREG_01473
Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.994
UREG_02971
Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.990
UREG_01628
3-ketoacyl-CoA thiolase B; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.987
UREG_03622
3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.987
UREG_05293
3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.987
UREG_06412
Pyruvate carboxyltransferase domain-containing protein.
     
 0.979
UREG_05484
Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
    
 0.945
UREG_07436
Uncharacterized protein.
  
 
 0.940
UREG_03325
Acetoacetate-CoA ligase.
   
 
 0.924
Your Current Organism:
Uncinocarpus reesii
NCBI taxonomy Id: 336963
Other names: U. reesii 1704, Uncinocarpus reesii 1704
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.