node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKAN_00129700 | CKAN_00303400 | A0A443N3E2 | A0A3S3MJ34 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ERCC4 domain-containing protein. | 0.963 |
CKAN_00129700 | CKAN_00448200 | A0A443N3E2 | A0A3S3NAZ6 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA repair endonuclease UVH1. | 0.977 |
CKAN_00129700 | CKAN_00548900 | A0A443N3E2 | A0A3S3NCL8 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA topoisomerase 1 isoform X1. | 0.877 |
CKAN_00129700 | CKAN_00596000 | A0A443N3E2 | A0A3S3MPR0 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Tudor domain-containing protein 3. | 0.995 |
CKAN_00129700 | CKAN_00878700 | A0A443N3E2 | A0A443NNQ7 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATP-dependent DNA helicase RecQ-like protein. | 0.998 |
CKAN_00129700 | CKAN_00945800 | A0A443N3E2 | A0A3S4NRY1 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA excision repair protein ERCC-1 isoform X1. | 0.630 |
CKAN_00129700 | CKAN_01579200 | A0A443N3E2 | A0A3S3PAV2 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATP-dependent DNA helicase mph1 isoform X1. | 0.982 |
CKAN_00129700 | CKAN_01585200 | A0A443N3E2 | A0A443P815 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.886 |
CKAN_00129700 | CKAN_02467800 | A0A443N3E2 | A0A443PX49 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | NPL4-like protein 2. | 0.762 |
CKAN_00303400 | CKAN_00129700 | A0A3S3MJ34 | A0A443N3E2 | ERCC4 domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.963 |
CKAN_00303400 | CKAN_00448200 | A0A3S3MJ34 | A0A3S3NAZ6 | ERCC4 domain-containing protein. | DNA repair endonuclease UVH1. | 0.958 |
CKAN_00303400 | CKAN_00548900 | A0A3S3MJ34 | A0A3S3NCL8 | ERCC4 domain-containing protein. | DNA topoisomerase 1 isoform X1. | 0.960 |
CKAN_00303400 | CKAN_00596000 | A0A3S3MJ34 | A0A3S3MPR0 | ERCC4 domain-containing protein. | Tudor domain-containing protein 3. | 0.989 |
CKAN_00303400 | CKAN_00878700 | A0A3S3MJ34 | A0A443NNQ7 | ERCC4 domain-containing protein. | ATP-dependent DNA helicase RecQ-like protein. | 0.997 |
CKAN_00303400 | CKAN_00945800 | A0A3S3MJ34 | A0A3S4NRY1 | ERCC4 domain-containing protein. | DNA excision repair protein ERCC-1 isoform X1. | 0.993 |
CKAN_00303400 | CKAN_01122500 | A0A3S3MJ34 | A0A443NVG2 | ERCC4 domain-containing protein. | E3 ubiquitin-protein ligase FANCL isoform X1. | 0.977 |
CKAN_00303400 | CKAN_01579200 | A0A3S3MJ34 | A0A3S3PAV2 | ERCC4 domain-containing protein. | ATP-dependent DNA helicase mph1 isoform X1. | 0.986 |
CKAN_00303400 | CKAN_01585200 | A0A3S3MJ34 | A0A443P815 | ERCC4 domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.960 |
CKAN_00303400 | CKAN_02467800 | A0A3S3MJ34 | A0A443PX49 | ERCC4 domain-containing protein. | NPL4-like protein 2. | 0.975 |
CKAN_00448200 | CKAN_00129700 | A0A3S3NAZ6 | A0A443N3E2 | DNA repair endonuclease UVH1. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.977 |