RN09_0010 protein (Mycobacterium tuberculosis variant africanum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

RN09_0010

Membrane protein. (201 aa)

Predicted Functional Partners:

RN09_0011

0.954

RN09_0008

0.776

GyrA

0.776

RN09_0007

0.700

RN09_1136

0.475

RN09_3364

0.475

gyrB

0.468

RpfA

0.452

RN09_1590

0.452

RpfC

0.452

Your Current Organism:

Mycobacterium tuberculosis variant africanum

NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GyrA	RN09_0007	RN09_0009	RN09_0007	DNA gyrase subunit A; Overlaps another CDS with the same product name.	DNA gyrase subunit A.	0.990
GyrA	RN09_0008	RN09_0009	RN09_0008	DNA gyrase subunit A; Overlaps another CDS with the same product name.	DNA gyrase subunit A; Overlaps another CDS with the same product name.	0.997
GyrA	RN09_0010	RN09_0009	RN09_0010	DNA gyrase subunit A; Overlaps another CDS with the same product name.	Membrane protein.	0.776
GyrA	RN09_0011	RN09_0009	RN09_0011	DNA gyrase subunit A; Overlaps another CDS with the same product name.	Membrane protein.	0.761
GyrA	gyrB	RN09_0009	RN09_0006	DNA gyrase subunit A; Overlaps another CDS with the same product name.	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.999
RN09_0007	GyrA	RN09_0007	RN09_0009	DNA gyrase subunit A.	DNA gyrase subunit A; Overlaps another CDS with the same product name.	0.990
RN09_0007	RN09_0008	RN09_0007	RN09_0008	DNA gyrase subunit A.	DNA gyrase subunit A; Overlaps another CDS with the same product name.	0.990
RN09_0007	RN09_0010	RN09_0007	RN09_0010	DNA gyrase subunit A.	Membrane protein.	0.700
RN09_0007	RN09_0011	RN09_0007	RN09_0011	DNA gyrase subunit A.	Membrane protein.	0.700
RN09_0007	gyrB	RN09_0007	RN09_0006	DNA gyrase subunit A.	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.995
RN09_0008	GyrA	RN09_0008	RN09_0009	DNA gyrase subunit A; Overlaps another CDS with the same product name.	DNA gyrase subunit A; Overlaps another CDS with the same product name.	0.997
RN09_0008	RN09_0007	RN09_0008	RN09_0007	DNA gyrase subunit A; Overlaps another CDS with the same product name.	DNA gyrase subunit A.	0.990
RN09_0008	RN09_0010	RN09_0008	RN09_0010	DNA gyrase subunit A; Overlaps another CDS with the same product name.	Membrane protein.	0.776
RN09_0008	RN09_0011	RN09_0008	RN09_0011	DNA gyrase subunit A; Overlaps another CDS with the same product name.	Membrane protein.	0.761
RN09_0008	gyrB	RN09_0008	RN09_0006	DNA gyrase subunit A; Overlaps another CDS with the same product name.	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.994
RN09_0010	GyrA	RN09_0010	RN09_0009	Membrane protein.	DNA gyrase subunit A; Overlaps another CDS with the same product name.	0.776
RN09_0010	RN09_0007	RN09_0010	RN09_0007	Membrane protein.	DNA gyrase subunit A.	0.700
RN09_0010	RN09_0008	RN09_0010	RN09_0008	Membrane protein.	DNA gyrase subunit A; Overlaps another CDS with the same product name.	0.776
RN09_0010	RN09_0011	RN09_0010	RN09_0011	Membrane protein.	Membrane protein.	0.954
RN09_0010	RN09_1136	RN09_0010	RN09_1136	Membrane protein.	Hypothetical protein.	0.475