STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RN09_0010Membrane protein. (201 aa)    
Predicted Functional Partners:
RN09_0011
Membrane protein.
      0.954
RN09_0008
DNA gyrase subunit A; Overlaps another CDS with the same product name.
  
  
 0.797
GyrA
DNA gyrase subunit A; Overlaps another CDS with the same product name.
  
  
 0.797
RN09_0007
DNA gyrase subunit A.
  
  
 0.711
RN09_1136
Hypothetical protein.
   
  
 0.509
RN09_3364
Hypothetical protein.
   
  
 0.509
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.491
RpfA
Resuscitation-promoting factor RpfA.
   
    0.459
RN09_1590
Hypothetical protein.
   
    0.459
RpfC
Resuscitation-promoting factor RpfC.
   
    0.459
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.