node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pcar_1503 | rdgB | Pcar_1503 | Pcar_2029 | Manganese/nickel-dependent phosphodiesterase, YfcE family. | Xanthosine/inosine triphosphate pyrophosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.738 |
Pcar_2031 | rdgB | Pcar_2031 | Pcar_2029 | N-acetylmuramyl-L-alanine amidase. | Xanthosine/inosine triphosphate pyrophosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.839 |
Pcar_2031 | rph | Pcar_2031 | Pcar_2030 | N-acetylmuramyl-L-alanine amidase. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.819 |
Pcar_2547 | Pcar_2563 | Pcar_2547 | Pcar_2563 | Hypoxanthine/guanine phosphoribosyltransferase, putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Glutamine-dependent amidotransferase, class I. | 0.921 |
Pcar_2547 | guaA | Pcar_2547 | Pcar_1218 | Hypoxanthine/guanine phosphoribosyltransferase, putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | 0.953 |
Pcar_2547 | guaB | Pcar_2547 | Pcar_1217 | Hypoxanthine/guanine phosphoribosyltransferase, putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.939 |
Pcar_2547 | rdgB | Pcar_2547 | Pcar_2029 | Hypoxanthine/guanine phosphoribosyltransferase, putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthosine/inosine triphosphate pyrophosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.909 |
Pcar_2547 | surE | Pcar_2547 | Pcar_1426 | Hypoxanthine/guanine phosphoribosyltransferase, putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Nucleoside 3'/5'-monophosphate phosphatase and short-chain exopolyphosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Pcar_2563 | Pcar_2547 | Pcar_2563 | Pcar_2547 | Glutamine-dependent amidotransferase, class I. | Hypoxanthine/guanine phosphoribosyltransferase, putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.921 |
Pcar_2563 | guaA | Pcar_2563 | Pcar_1218 | Glutamine-dependent amidotransferase, class I. | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | 0.951 |
Pcar_2563 | guaB | Pcar_2563 | Pcar_1217 | Glutamine-dependent amidotransferase, class I. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.973 |
Pcar_2563 | rdgB | Pcar_2563 | Pcar_2029 | Glutamine-dependent amidotransferase, class I. | Xanthosine/inosine triphosphate pyrophosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.910 |
Pcar_2563 | surE | Pcar_2563 | Pcar_1426 | Glutamine-dependent amidotransferase, class I. | Nucleoside 3'/5'-monophosphate phosphatase and short-chain exopolyphosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.929 |
guaA | Pcar_2547 | Pcar_1218 | Pcar_2547 | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine/guanine phosphoribosyltransferase, putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.953 |
guaA | Pcar_2563 | Pcar_1218 | Pcar_2563 | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | Glutamine-dependent amidotransferase, class I. | 0.951 |
guaA | guaB | Pcar_1218 | Pcar_1217 | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | ndk | Pcar_1218 | Pcar_2023 | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.570 |
guaA | rdgB | Pcar_1218 | Pcar_2029 | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | Xanthosine/inosine triphosphate pyrophosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.977 |
guaA | rph | Pcar_1218 | Pcar_2030 | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.440 |
guaA | surE | Pcar_1218 | Pcar_1426 | Guanosine-5'-monophosphate synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside 3'/5'-monophosphate phosphatase and short-chain exopolyphosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.952 |