node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pcar_2051 | Pcar_2864 | Pcar_2051 | Pcar_2864 | Helicase, putative. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.945 |
Pcar_2051 | dnaN | Pcar_2051 | Pcar_0002 | Helicase, putative. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.664 |
Pcar_2051 | polA | Pcar_2051 | Pcar_0592 | Helicase, putative. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.945 |
Pcar_2051 | recA | Pcar_2051 | Pcar_2405 | Helicase, putative. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.906 |
Pcar_2051 | recQ | Pcar_2051 | Pcar_2380 | Helicase, putative. | ATP-dependent DNA helicase RecQ. | 0.918 |
Pcar_2051 | sbcC-2 | Pcar_2051 | Pcar_1375 | Helicase, putative. | DNA repair exonuclease SbcCD, C subunit, putative. | 0.903 |
Pcar_2051 | topA | Pcar_2051 | Pcar_0406 | Helicase, putative. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.958 |
Pcar_2864 | Pcar_2051 | Pcar_2864 | Pcar_2051 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Helicase, putative. | 0.945 |
Pcar_2864 | dnaN | Pcar_2864 | Pcar_0002 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.970 |
Pcar_2864 | lexA | Pcar_2864 | Pcar_1739 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.433 |
Pcar_2864 | polA | Pcar_2864 | Pcar_0592 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.882 |
Pcar_2864 | recA | Pcar_2864 | Pcar_2405 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.976 |
Pcar_2864 | recQ | Pcar_2864 | Pcar_2380 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | ATP-dependent DNA helicase RecQ. | 0.945 |
Pcar_2864 | recX | Pcar_2864 | Pcar_2407 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Recombination regulator RecX; Modulates RecA activity; Belongs to the RecX family. | 0.521 |
Pcar_2864 | sbcC-2 | Pcar_2864 | Pcar_1375 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA repair exonuclease SbcCD, C subunit, putative. | 0.907 |
Pcar_2864 | topA | Pcar_2864 | Pcar_0406 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.902 |
alaS | recA | Pcar_2408 | Pcar_2405 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.873 |
alaS | recX | Pcar_2408 | Pcar_2407 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | Recombination regulator RecX; Modulates RecA activity; Belongs to the RecX family. | 0.801 |
dnaN | Pcar_2051 | Pcar_0002 | Pcar_2051 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Helicase, putative. | 0.664 |
dnaN | Pcar_2864 | Pcar_0002 | Pcar_2864 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.970 |