node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobQ | hisA | Pcar_0484 | Pcar_2685 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.882 |
cobQ | hisB | Pcar_0484 | Pcar_2687 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Imidazoleglycerol-phosphate dehydratase. | 0.887 |
cobQ | hisD | Pcar_0484 | Pcar_2688 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.883 |
cobQ | hisF | Pcar_0484 | Pcar_2684 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.882 |
cobQ | hisGS | Pcar_0484 | Pcar_2689 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | ATP phosphoribosyltransferase, short form; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.894 |
cobQ | hisH | Pcar_0484 | Pcar_2686 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.893 |
cobQ | hisI | Pcar_0484 | Pcar_2024 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.750 |
cobQ | hisIE | Pcar_0484 | Pcar_2683 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase. | 0.963 |
hisA | cobQ | Pcar_2685 | Pcar_0484 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.882 |
hisA | hisB | Pcar_2685 | Pcar_2687 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.997 |
hisA | hisC | Pcar_2685 | Pcar_0321 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.965 |
hisA | hisD | Pcar_2685 | Pcar_2688 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisF | Pcar_2685 | Pcar_2684 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisGS | Pcar_2685 | Pcar_2689 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase, short form; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.993 |
hisA | hisH | Pcar_2685 | Pcar_2686 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Pcar_2685 | Pcar_2024 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisIE | Pcar_2685 | Pcar_2683 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase. | 0.999 |
hisA | trpF | Pcar_2685 | Pcar_0734 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.857 |
hisB | cobQ | Pcar_2687 | Pcar_0484 | Imidazoleglycerol-phosphate dehydratase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.887 |
hisB | hisA | Pcar_2687 | Pcar_2685 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.997 |