node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ppro_0055 | Ppro_0283 | Ppro_0055 | Ppro_0283 | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.947 |
Ppro_0055 | Ppro_1587 | Ppro_0055 | Ppro_1587 | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | 0.917 |
Ppro_0055 | fmt | Ppro_0055 | Ppro_0513 | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.925 |
Ppro_0055 | folD | Ppro_0055 | Ppro_0480 | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
Ppro_0055 | glyA | Ppro_0055 | Ppro_1748 | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
Ppro_0055 | purN | Ppro_0055 | Ppro_1773 | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.918 |
Ppro_0055 | thyX | Ppro_0055 | Ppro_2649 | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.914 |
Ppro_0283 | Ppro_0055 | Ppro_0283 | Ppro_0055 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: ade:Adeh_3969 methionyl-tRNA formyltransferase. | 0.947 |
Ppro_0283 | Ppro_1089 | Ppro_0283 | Ppro_1089 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | KEGG: dvu:DVU0997 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.962 |
Ppro_0283 | Ppro_1587 | Ppro_0283 | Ppro_1587 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | 0.960 |
Ppro_0283 | Ppro_3313 | Ppro_0283 | Ppro_3313 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: gsu:GSU1136 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.458 |
Ppro_0283 | fmt | Ppro_0283 | Ppro_0513 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.947 |
Ppro_0283 | folD | Ppro_0283 | Ppro_0480 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.950 |
Ppro_0283 | glyA | Ppro_0283 | Ppro_1748 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
Ppro_0283 | purH | Ppro_0283 | Ppro_2592 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | IMP cyclohydrolase; KEGG: gsu:GSU0609 phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.943 |
Ppro_0283 | purN | Ppro_0283 | Ppro_1773 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.944 |
Ppro_0283 | thyX | Ppro_0283 | Ppro_2649 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.918 |
Ppro_1089 | Ppro_0283 | Ppro_1089 | Ppro_0283 | KEGG: dvu:DVU0997 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: gme:Gmet_0504 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.962 |
Ppro_1089 | Ppro_1587 | Ppro_1089 | Ppro_1587 | KEGG: dvu:DVU0997 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | 0.923 |
Ppro_1089 | folD | Ppro_1089 | Ppro_0480 | KEGG: dvu:DVU0997 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |