STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (314 aa)    
Predicted Functional Partners:
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.998
Ppro_2238
PFAM: biotin/lipoate A/B protein ligase; KEGG: gme:Gmet_3151 biotin/lipoate A/B protein ligase.
  
 
 0.925
lipA-2
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
  
  
 
0.906
gcvH-2
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.787
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
   
 0.757
Ppro_1030
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: pca:Pcar_0347 2-oxoglutarate dehydrogenase complex, E3 component, lipoamide dehydrogenase.
 
  
 0.748
Ppro_1026
PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; KEGG: pca:Pcar_0345 dehydrogenase complex E2 component, dihydrolipamide acetyltransferase.
 
  
 0.725
Ppro_1043
PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: pca:Pcar_0330 2,3-butanediol dehydrogenase.
     
 0.684
Ppro_1024
Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase, E1 component; KEGG: pca:Pcar_0343 acetoin dehydrogenase complex, E1 component, alpha subunit.
     
 0.652
Ppro_1028
PFAM: Transketolase, central region; Transketolase domain protein; KEGG: reu:Reut_B5551 transketolase, central region:transketolase, C-terminal.
  
  
 0.539
Your Current Organism:
Pelobacter propionicus
NCBI taxonomy Id: 338966
Other names: P. propionicus DSM 2379, Pelobacter propionicus DSM 2379, Pelobacter propionicus str. DSM 2379, Pelobacter propionicus strain DSM 2379
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