node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ppro_1178 | Ppro_1179 | Ppro_1178 | Ppro_1179 | Hypothetical protein. | Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase; KEGG: gme:Gmet_0812 two component, sigma54 specific, transcriptional regulator, fis family. | 0.773 |
Ppro_1178 | bioA | Ppro_1178 | Ppro_1177 | Hypothetical protein. | Aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.773 |
Ppro_1178 | bioB | Ppro_1178 | Ppro_1175 | Hypothetical protein. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.634 |
Ppro_1178 | bioD | Ppro_1178 | Ppro_1176 | Hypothetical protein. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.634 |
Ppro_1179 | Ppro_1178 | Ppro_1179 | Ppro_1178 | Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase; KEGG: gme:Gmet_0812 two component, sigma54 specific, transcriptional regulator, fis family. | Hypothetical protein. | 0.773 |
Ppro_1179 | bioA | Ppro_1179 | Ppro_1177 | Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase; KEGG: gme:Gmet_0812 two component, sigma54 specific, transcriptional regulator, fis family. | Aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.773 |
Ppro_1179 | bioB | Ppro_1179 | Ppro_1175 | Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase; KEGG: gme:Gmet_0812 two component, sigma54 specific, transcriptional regulator, fis family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.634 |
Ppro_1179 | bioD | Ppro_1179 | Ppro_1176 | Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase; KEGG: gme:Gmet_0812 two component, sigma54 specific, transcriptional regulator, fis family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.634 |
Ppro_1491 | Ppro_2767 | Ppro_1491 | Ppro_2767 | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | Serine palmitoyltransferase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III; KEGG: nmu:Nmul_A0228 8-amino-7-oxononanoate synthase. | 0.721 |
Ppro_1491 | bioA | Ppro_1491 | Ppro_1177 | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | Aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.837 |
Ppro_1491 | bioB | Ppro_1491 | Ppro_1175 | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.906 |
Ppro_1491 | bioD | Ppro_1491 | Ppro_1176 | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.987 |
Ppro_1491 | bioF | Ppro_1491 | Ppro_2093 | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.721 |
Ppro_1491 | birA | Ppro_1491 | Ppro_0654 | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.952 |
Ppro_1491 | thiE | Ppro_1491 | Ppro_2595 | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.581 |
Ppro_2767 | Ppro_1491 | Ppro_2767 | Ppro_1491 | Serine palmitoyltransferase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III; KEGG: nmu:Nmul_A0228 8-amino-7-oxononanoate synthase. | Iron-only hydrogenase maturation protein HydE; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pca:Pcar_1607 biotin synthase. | 0.721 |
Ppro_2767 | bioA | Ppro_2767 | Ppro_1177 | Serine palmitoyltransferase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III; KEGG: nmu:Nmul_A0228 8-amino-7-oxononanoate synthase. | Aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.981 |
Ppro_2767 | bioB | Ppro_2767 | Ppro_1175 | Serine palmitoyltransferase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III; KEGG: nmu:Nmul_A0228 8-amino-7-oxononanoate synthase. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.770 |
Ppro_2767 | bioD | Ppro_2767 | Ppro_1176 | Serine palmitoyltransferase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III; KEGG: nmu:Nmul_A0228 8-amino-7-oxononanoate synthase. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.912 |
Ppro_2767 | bioF | Ppro_2767 | Ppro_2093 | Serine palmitoyltransferase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III; KEGG: nmu:Nmul_A0228 8-amino-7-oxononanoate synthase. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.913 |