node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ppro_0442 | Ppro_3374 | Ppro_0442 | Ppro_3374 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | 0.996 |
Ppro_0442 | Ppro_3379 | Ppro_0442 | Ppro_3379 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; KEGG: gsu:GSU3282 siroheme synthase, N-terminal domain protein. | 0.629 |
Ppro_0442 | hemA | Ppro_0442 | Ppro_3377 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.891 |
Ppro_0442 | hemC | Ppro_0442 | Ppro_3375 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
Ppro_0442 | hemE | Ppro_0442 | Ppro_0619 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.684 |
Ppro_0442 | hemL | Ppro_0442 | Ppro_2666 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gsu:GSU0337 glutamate-1-semialdehyde-2,1-aminomutase. | 0.995 |
Ppro_0442 | thiE | Ppro_0442 | Ppro_2595 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.512 |
Ppro_2667 | Ppro_2668 | Ppro_2667 | Ppro_2668 | KEGG: gsu:GSU0336 hypothetical protein. | KEGG: gme:Gmet_3358 hypothetical protein. | 0.918 |
Ppro_2667 | hemL | Ppro_2667 | Ppro_2666 | KEGG: gsu:GSU0336 hypothetical protein. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gsu:GSU0337 glutamate-1-semialdehyde-2,1-aminomutase. | 0.660 |
Ppro_2668 | Ppro_2667 | Ppro_2668 | Ppro_2667 | KEGG: gme:Gmet_3358 hypothetical protein. | KEGG: gsu:GSU0336 hypothetical protein. | 0.918 |
Ppro_2668 | hemL | Ppro_2668 | Ppro_2666 | KEGG: gme:Gmet_3358 hypothetical protein. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gsu:GSU0337 glutamate-1-semialdehyde-2,1-aminomutase. | 0.654 |
Ppro_3135 | hemL | Ppro_3135 | Ppro_2666 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; protein of unknown function DUF224, cysteine-rich region domain protein; KEGG: dsy:DSY1921 hypothetical protein. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gsu:GSU0337 glutamate-1-semialdehyde-2,1-aminomutase. | 0.643 |
Ppro_3374 | Ppro_0442 | Ppro_3374 | Ppro_0442 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.996 |
Ppro_3374 | Ppro_3379 | Ppro_3374 | Ppro_3379 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; KEGG: gsu:GSU3282 siroheme synthase, N-terminal domain protein. | 0.999 |
Ppro_3374 | hemA | Ppro_3374 | Ppro_3377 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.976 |
Ppro_3374 | hemC | Ppro_3374 | Ppro_3375 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Ppro_3374 | hemE | Ppro_3374 | Ppro_0619 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.953 |
Ppro_3374 | hemL | Ppro_3374 | Ppro_2666 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gsu:GSU0337 glutamate-1-semialdehyde-2,1-aminomutase. | 0.881 |
Ppro_3374 | thiE | Ppro_3374 | Ppro_2595 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gsu:GSU3286 uroporphyrinogen III synthase/methyltransferase. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.496 |
Ppro_3379 | Ppro_0442 | Ppro_3379 | Ppro_0442 | Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; KEGG: gsu:GSU3282 siroheme synthase, N-terminal domain protein. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gsu:GSU0135 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.629 |