node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | Ppro_3056 | Ppro_3040 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | 0.990 |
hisA | hisD | Ppro_3056 | Ppro_3042 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.990 |
hisA | hisE | Ppro_3056 | Ppro_3054 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: gme:Gmet_0390 phosphoribosyl-ATP pyrophosphohydrolase. | 0.997 |
hisA | hisF | Ppro_3056 | Ppro_3055 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Ppro_3056 | Ppro_2945 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.883 |
hisA | hisG-2 | Ppro_3056 | Ppro_3043 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.961 |
hisA | hisH | Ppro_3056 | Ppro_3057 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Ppro_3056 | Ppro_2944 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | Ppro_3040 | Ppro_3056 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.990 |
hisB | hisD | Ppro_3040 | Ppro_3042 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Ppro_3040 | Ppro_3054 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: gme:Gmet_0390 phosphoribosyl-ATP pyrophosphohydrolase. | 0.986 |
hisB | hisF | Ppro_3040 | Ppro_3055 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Ppro_3040 | Ppro_2945 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.929 |
hisB | hisG-2 | Ppro_3040 | Ppro_3043 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.987 |
hisB | hisH | Ppro_3040 | Ppro_3057 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Ppro_3040 | Ppro_2944 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.990 |
hisD | hisA | Ppro_3042 | Ppro_3056 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: gsu:GSU3096 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.990 |
hisD | hisB | Ppro_3042 | Ppro_3040 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gme:Gmet_0386 imidazoleglycerol-phosphate dehydratase. | 0.999 |
hisD | hisE | Ppro_3042 | Ppro_3054 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: gme:Gmet_0390 phosphoribosyl-ATP pyrophosphohydrolase. | 0.987 |
hisD | hisF | Ppro_3042 | Ppro_3055 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |