node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asuc_0636 | guaA | Asuc_0636 | Asuc_0896 | KEGG: msu:MS1885 glutamine amidotransferase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.454 |
Asuc_0636 | hisA | Asuc_0636 | Asuc_1768 | KEGG: msu:MS1885 glutamine amidotransferase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.837 |
Asuc_0636 | hisB | Asuc_0636 | Asuc_0634 | KEGG: msu:MS1885 glutamine amidotransferase. | TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; KEGG: pmu:PM1200 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.988 |
Asuc_0636 | hisC | Asuc_0636 | Asuc_0633 | KEGG: msu:MS1885 glutamine amidotransferase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: msu:MS1891 histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.895 |
Asuc_0636 | hisC-2 | Asuc_0636 | Asuc_0923 | KEGG: msu:MS1885 glutamine amidotransferase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: msu:MS1574 histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.613 |
Asuc_0636 | hisD | Asuc_0636 | Asuc_0631 | KEGG: msu:MS1885 glutamine amidotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.850 |
Asuc_0636 | hisF | Asuc_0636 | Asuc_1769 | KEGG: msu:MS1885 glutamine amidotransferase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.948 |
Asuc_0636 | hisG | Asuc_0636 | Asuc_0630 | KEGG: msu:MS1885 glutamine amidotransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.911 |
Asuc_0636 | hisI | Asuc_0636 | Asuc_1770 | KEGG: msu:MS1885 glutamine amidotransferase. | PFAM: phosphoribosyl-AMP cyclohydrolase; MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: msu:MS1881 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.979 |
guaA | Asuc_0636 | Asuc_0896 | Asuc_0636 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | KEGG: msu:MS1885 glutamine amidotransferase. | 0.454 |
guaA | hisA | Asuc_0896 | Asuc_1768 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.757 |
guaA | hisB | Asuc_0896 | Asuc_0634 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; KEGG: pmu:PM1200 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.488 |
guaA | hisF | Asuc_0896 | Asuc_1769 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.470 |
guaA | hisH | Asuc_0896 | Asuc_1766 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.454 |
guaA | hisI | Asuc_0896 | Asuc_1770 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | PFAM: phosphoribosyl-AMP cyclohydrolase; MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: msu:MS1881 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.450 |
hisA | Asuc_0636 | Asuc_1768 | Asuc_0636 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | KEGG: msu:MS1885 glutamine amidotransferase. | 0.837 |
hisA | guaA | Asuc_1768 | Asuc_0896 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.757 |
hisA | hisB | Asuc_1768 | Asuc_0634 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; KEGG: pmu:PM1200 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.991 |
hisA | hisC | Asuc_1768 | Asuc_0633 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: msu:MS1891 histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.923 |
hisA | hisC-2 | Asuc_1768 | Asuc_0923 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: msu:MS1574 histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.776 |