node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCAG_00339 | KAE1 | A6QSI3 | A6RF13 | Uncharacterized protein. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.516 |
HCAG_01153 | HCAG_03689 | A6QUU7 | A6R231 | Protein kinase domain-containing protein. | YrdC-like domain-containing protein. | 0.611 |
HCAG_01153 | HCAG_04536 | A6QUU7 | A6R4H8 | Protein kinase domain-containing protein. | Uncharacterized protein; Belongs to the CGI121/TPRKB family. | 0.997 |
HCAG_01153 | KAE1 | A6QUU7 | A6RF13 | Protein kinase domain-containing protein. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.997 |
HCAG_03642 | HCAG_03689 | A6R1Y4 | A6R231 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | YrdC-like domain-containing protein. | 0.470 |
HCAG_03642 | HCAG_06876 | A6R1Y4 | A6R985 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | Uncharacterized protein. | 0.660 |
HCAG_03642 | KAE1 | A6R1Y4 | A6RF13 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.430 |
HCAG_03689 | HCAG_01153 | A6R231 | A6QUU7 | YrdC-like domain-containing protein. | Protein kinase domain-containing protein. | 0.611 |
HCAG_03689 | HCAG_03642 | A6R231 | A6R1Y4 | YrdC-like domain-containing protein. | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.470 |
HCAG_03689 | HCAG_04536 | A6R231 | A6R4H8 | YrdC-like domain-containing protein. | Uncharacterized protein; Belongs to the CGI121/TPRKB family. | 0.608 |
HCAG_03689 | HCAG_06876 | A6R231 | A6R985 | YrdC-like domain-containing protein. | Uncharacterized protein. | 0.630 |
HCAG_03689 | KAE1 | A6R231 | A6RF13 | YrdC-like domain-containing protein. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.816 |
HCAG_03972 | KAE1 | A6R2W4 | A6RF13 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.479 |
HCAG_04101 | KAE1 | A6R393 | A6RF13 | Proteasome component C5. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.639 |
HCAG_04536 | HCAG_01153 | A6R4H8 | A6QUU7 | Uncharacterized protein; Belongs to the CGI121/TPRKB family. | Protein kinase domain-containing protein. | 0.997 |
HCAG_04536 | HCAG_03689 | A6R4H8 | A6R231 | Uncharacterized protein; Belongs to the CGI121/TPRKB family. | YrdC-like domain-containing protein. | 0.608 |
HCAG_04536 | KAE1 | A6R4H8 | A6RF13 | Uncharacterized protein; Belongs to the CGI121/TPRKB family. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.997 |
HCAG_05162 | KAE1 | A6R6A4 | A6RF13 | Uncharacterized protein. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.439 |
HCAG_06876 | HCAG_03642 | A6R985 | A6R1Y4 | Uncharacterized protein. | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.660 |
HCAG_06876 | HCAG_03689 | A6R985 | A6R231 | Uncharacterized protein. | YrdC-like domain-containing protein. | 0.630 |