STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmBPsmB; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (205 aa)    
Predicted Functional Partners:
psmA
PsmA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.999
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
  
 0.958
Msp_1146
Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310.
   
 0.939
rpl40e
50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.864
cdcH
CdcH; Predicted cell division protein 48; COG464, pfam02933, pfam02359, pfam00004.
  
 0.798
Msp_1550
Predicted ATP-dependent 26S proteasome regulatory subunit; COG1222, pfam00004.
  
 0.797
iscS
IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
      0.706
Msp_0281
Predicted exonuclease; Involved in RNA processing; COG1236, pfam00753.
 
   
 0.649
rpl4
50S ribosomal protein L1e; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
 
 
 0.611
ef1b
Elongation factor 1-beta (aEF-1beta) (ef1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
  
 
 0.595
Your Current Organism:
Methanosphaera stadtmanae
NCBI taxonomy Id: 339860
Other names: M. stadtmanae DSM 3091, Methanosphaera stadtmanae ATCC 43021, Methanosphaera stadtmanae DSM 3091, Methanosphaera stadtmanae MCB-3, Methanosphaera stadtmanae str. DSM 3091, Methanosphaera stadtmanae strain DSM 3091
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