node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msp_0281 | psmB | Msp_0281 | Msp_0282 | Predicted exonuclease; Involved in RNA processing; COG1236, pfam00753. | PsmB; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.649 |
Msp_1146 | Msp_1550 | Msp_1146 | Msp_1550 | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | Predicted ATP-dependent 26S proteasome regulatory subunit; COG1222, pfam00004. | 0.768 |
Msp_1146 | cdcH | Msp_1146 | Msp_1084 | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | CdcH; Predicted cell division protein 48; COG464, pfam02933, pfam02359, pfam00004. | 0.768 |
Msp_1146 | ef1b | Msp_1146 | Msp_1159 | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | Elongation factor 1-beta (aEF-1beta) (ef1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | 0.432 |
Msp_1146 | pan | Msp_1146 | Msp_1206 | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.998 |
Msp_1146 | psmA | Msp_1146 | Msp_1248 | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | PsmA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.939 |
Msp_1146 | psmB | Msp_1146 | Msp_0282 | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | PsmB; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.939 |
Msp_1146 | rpl40e | Msp_1146 | Msp_1292 | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.986 |
Msp_1550 | Msp_1146 | Msp_1550 | Msp_1146 | Predicted ATP-dependent 26S proteasome regulatory subunit; COG1222, pfam00004. | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | 0.768 |
Msp_1550 | pan | Msp_1550 | Msp_1206 | Predicted ATP-dependent 26S proteasome regulatory subunit; COG1222, pfam00004. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.728 |
Msp_1550 | psmA | Msp_1550 | Msp_1248 | Predicted ATP-dependent 26S proteasome regulatory subunit; COG1222, pfam00004. | PsmA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.805 |
Msp_1550 | psmB | Msp_1550 | Msp_0282 | Predicted ATP-dependent 26S proteasome regulatory subunit; COG1222, pfam00004. | PsmB; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.797 |
Msp_1550 | rpl40e | Msp_1550 | Msp_1292 | Predicted ATP-dependent 26S proteasome regulatory subunit; COG1222, pfam00004. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.904 |
cdcH | Msp_1146 | Msp_1084 | Msp_1146 | CdcH; Predicted cell division protein 48; COG464, pfam02933, pfam02359, pfam00004. | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | 0.768 |
cdcH | pan | Msp_1084 | Msp_1206 | CdcH; Predicted cell division protein 48; COG464, pfam02933, pfam02359, pfam00004. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.703 |
cdcH | psmA | Msp_1084 | Msp_1248 | CdcH; Predicted cell division protein 48; COG464, pfam02933, pfam02359, pfam00004. | PsmA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.808 |
cdcH | psmB | Msp_1084 | Msp_0282 | CdcH; Predicted cell division protein 48; COG464, pfam02933, pfam02359, pfam00004. | PsmB; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.798 |
cdcH | rpl40e | Msp_1084 | Msp_1292 | CdcH; Predicted cell division protein 48; COG464, pfam02933, pfam02359, pfam00004. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.904 |
ef1b | Msp_1146 | Msp_1159 | Msp_1146 | Elongation factor 1-beta (aEF-1beta) (ef1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | Partially conserved hypothetical protein; Related to metal-dependent protease; COG1310. | 0.432 |
ef1b | psmA | Msp_1159 | Msp_1248 | Elongation factor 1-beta (aEF-1beta) (ef1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | PsmA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.606 |