STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate/lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (317 aa)    
Predicted Functional Partners:
Msp_0338
Fumarate hydratase.
  
 
 0.980
Msp_0791
Fumarate hydratase; COG1838, pfam05683.
  
 
 0.980
gap
Glyceraldehyde 3-phosphate dehydrogenase; COG0057, pfam02800, pfam00044.
  
 
 0.976
pycB
PycB; Pyruvate carboxylase; COG5016, pfam02436, pfam00682, pfam00364.
    
 0.946
Msp_0510
Putative aspartate aminotransferase; COG0436, pfam00155.
  
 0.937
comC
ComC; Putative L-sulfolactate dehydrogenase.
    
 0.933
pycA
PycA; Pyruvate carboxylase, subunit A.
    
 0.922
sucC
SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.918
rpl4
50S ribosomal protein L1e; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.917
gdhA
GdhA; Glutamate dehydrogenase; COG0334, pfam00208, pfam02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.906
Your Current Organism:
Methanosphaera stadtmanae
NCBI taxonomy Id: 339860
Other names: M. stadtmanae DSM 3091, Methanosphaera stadtmanae ATCC 43021, Methanosphaera stadtmanae DSM 3091, Methanosphaera stadtmanae MCB-3, Methanosphaera stadtmanae str. DSM 3091, Methanosphaera stadtmanae strain DSM 3091
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