STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gch3Putative GTP cyclohydrolase III; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. (255 aa)    
Predicted Functional Partners:
arfB
Predicted creatinine amidohydrolase; Catalyzes the hydrolysis of the formamide of 2-amino-5- formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
    
 0.931
purO
PurO; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
 
     0.861
Msp_0254
Anaerobic ribonucleotide-triphosphate reductase.
  
  
  0.835
cofE
CofE; Putative F420-0:gamma-L-glutamate ligase; pfam01996.
       0.814
cofD
CofD; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
       0.814
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
     
  0.800
Msp_1098
Predicted adenylate cyclase; COG1437.
     
  0.800
Msp_1405
Conserved hypothetical protein; Related to tRNA dihydrouridine synthase.
 
     0.711
aroK
AroK; Putative archaeal shikimate kinase.
  
     0.596
Msp_0916
Predicted selenocysteine synthase; COG1921, pfam03841.
  
     0.566
Your Current Organism:
Methanosphaera stadtmanae
NCBI taxonomy Id: 339860
Other names: M. stadtmanae DSM 3091, Methanosphaera stadtmanae ATCC 43021, Methanosphaera stadtmanae DSM 3091, Methanosphaera stadtmanae MCB-3, Methanosphaera stadtmanae str. DSM 3091, Methanosphaera stadtmanae strain DSM 3091
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