STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metH25-methyltetrahydrofolate-homocysteine methyltransferase; Methionine synthase I cobalamin-binding domain (918 aa)    
Predicted Functional Partners:
metH1
Methionine synthase I (cobalamin-dependent) methyltransferase domain
  
 0.999
metF1
510-methylenetetrahydrofolate reductase
 
 0.991
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
  
 
 0.978
metF2
510-methylenetetrahydrofolate reductase
   
 0.971
XCC2856
Cystathionine beta-lyases/cystathionine gamma-synthases
    
 0.969
metE
5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; Methionine synthase II (cobalamin-independent)
  
 
 0.964
metK
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
  
 
 0.960
thrA
Bifunctional aspartokinase/homoserine dehydrogenase I; Aspartokinases
  
 
 0.959
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
    
 0.953
XCC0597
Cystathionine beta-synthase; Cysteine synthase
  
 
 0.950
Your Current Organism:
Xanthomonas campestris campestris
NCBI taxonomy Id: 340
Other names: X. campestris pv. campestris, Xanthomonas campestris, Xanthomonas campestris (pv. campestris), Xanthomonas campestris campestris, Xanthomonas campestris pv. campestris
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