Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Glutathione S-transferase GST-4.5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily (204 aa)
Predicted Functional Partners:
Glutathione S-transferase (220 aa)
Reductase; Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component and related enzymes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family (456 aa)
Glutathione S-transferase (204 aa)
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) (316 aa)
Glutathione S-transferase (213 aa)
Glutathione S-transferase (211 aa)
Glutathione S-transferase; Belongs to the GST superfamily (246 aa)
Glutathione peroxidase; Belongs to the glutathione peroxidase family (161 aa)
Glutathione-S-transferases (235 aa)
Glutathione S-transferase; Belongs to the GST superfamily (232 aa)