node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABY94640.1 | hisC | Teth39_0985 | Teth39_0517 | PFAM: Prephenate dehydrogenase; TrkA-N domain protein; 6-phosphogluconate dehydrogenase, NAD-binding. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Allinase-like; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.964 |
ABY94640.1 | pheA | Teth39_0985 | Teth39_0983 | PFAM: Prephenate dehydrogenase; TrkA-N domain protein; 6-phosphogluconate dehydrogenase, NAD-binding. | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. | 0.991 |
hisA | hisB | Teth39_0520 | Teth39_0518 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | Teth39_0520 | Teth39_0517 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Allinase-like; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.971 |
hisA | hisD | Teth39_0520 | Teth39_0516 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisF | Teth39_0520 | Teth39_0521 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Teth39_0520 | Teth39_0515 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.998 |
hisA | hisH | Teth39_0520 | Teth39_0519 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Teth39_0520 | Teth39_0522 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | Teth39_0520 | Teth39_0514 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.972 |
hisB | hisA | Teth39_0518 | Teth39_0520 | PFAM: imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.998 |
hisB | hisC | Teth39_0518 | Teth39_0517 | PFAM: imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Allinase-like; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | Teth39_0518 | Teth39_0516 | PFAM: imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | Teth39_0518 | Teth39_0521 | PFAM: imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Teth39_0518 | Teth39_0515 | PFAM: imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
hisB | hisH | Teth39_0518 | Teth39_0519 | PFAM: imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Teth39_0518 | Teth39_0522 | PFAM: imidazoleglycerol-phosphate dehydratase. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | hisZ | Teth39_0518 | Teth39_0514 | PFAM: imidazoleglycerol-phosphate dehydratase. | Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.992 |
hisC | ABY94640.1 | Teth39_0517 | Teth39_0985 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Allinase-like; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | PFAM: Prephenate dehydrogenase; TrkA-N domain protein; 6-phosphogluconate dehydrogenase, NAD-binding. | 0.964 |
hisC | hisA | Teth39_0517 | Teth39_0520 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Allinase-like; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.971 |