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uvrA protein (Thermoanaerobacter pseudethanolicus) - STRING interaction network
"uvrA" - UvrABC system protein A in Thermoanaerobacter pseudethanolicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (927 aa)    
Predicted Functional Partners:
uvrB
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (661 aa)
 
 
  0.996
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5’ and 3’ sides of the lesion. The N-terminal half is responsible for the 3’ incision and the C-terminal half is responsible for the 5’ incision (615 aa)
 
 
  0.986
mfd
Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (1165 aa)
 
 
  0.907
ABY94235.1
FHA domain containing protein; PFAM- Forkhead-associated protein (134 aa)
         
  0.892
ABY94237.1
Peptidoglycan glycosyltransferase; PFAM- penicillin-binding protein, transpeptidase (473 aa)
         
  0.883
ABY94236.1
PFAM- cell cycle protein; Belongs to the SEDS family (414 aa)
         
  0.883
ABY95332.1
TIGRFAM- ATP-dependent DNA helicase PcrA; PFAM- UvrD/REP helicase (711 aa)
 
 
  0.807
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (386 aa)
   
 
  0.777
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (872 aa)
 
   
  0.770
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (807 aa)
 
   
  0.695
Your Current Organism:
Thermoanaerobacter pseudethanolicus
NCBI taxonomy Id: 340099
Other names: Clostridium thermohydrosulfuricum 39E, T. pseudethanolicus ATCC 33223, Thermoanaerobacter ethanolicus ATCC 33223, Thermoanaerobacter pseudethanolicus, Thermoanaerobacter pseudethanolicus 39E, Thermoanaerobacter pseudethanolicus ATCC 33223, Thermoanaerobacter pseudethanolicus ATCC33223, Thermoanaerobacter pseudethanolicus str. ATCC 33223, Thermoanaerobacter pseudethanolicus strain ATCC 33223
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