node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABY93991.1 | folE | Teth39_0322 | Teth39_0319 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | PFAM: GTP cyclohydrolase I. | 0.994 |
ABY93991.1 | guaA | Teth39_0322 | Teth39_1719 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.429 |
ABY93991.1 | queF | Teth39_0322 | Teth39_1438 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.827 |
ABY93991.1 | ribBA | Teth39_0322 | Teth39_0023 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.414 |
ABY95087.1 | queA | Teth39_1437 | Teth39_1016 | PFAM: protein of unknown function DUF988. | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.520 |
ABY95087.1 | queF | Teth39_1437 | Teth39_1438 | PFAM: protein of unknown function DUF988. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.846 |
ABY95087.1 | tgt | Teth39_1437 | Teth39_1017 | PFAM: protein of unknown function DUF988. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.452 |
folE | ABY93991.1 | Teth39_0319 | Teth39_0322 | PFAM: GTP cyclohydrolase I. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | 0.994 |
folE | queF | Teth39_0319 | Teth39_1438 | PFAM: GTP cyclohydrolase I. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.483 |
folE | ribBA | Teth39_0319 | Teth39_0023 | PFAM: GTP cyclohydrolase I. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.968 |
guaA | ABY93991.1 | Teth39_1719 | Teth39_0322 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. | 0.429 |
guaA | guaB | Teth39_1719 | Teth39_1720 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Response regulator receiver protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | queF | Teth39_1719 | Teth39_1438 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.616 |
guaA | ribBA | Teth39_1719 | Teth39_0023 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.808 |
guaA | tgt | Teth39_1719 | Teth39_1017 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.594 |
guaB | guaA | Teth39_1720 | Teth39_1719 | Response regulator receiver protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB | queF | Teth39_1720 | Teth39_1438 | Response regulator receiver protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.491 |
guaB | ribBA | Teth39_1720 | Teth39_0023 | Response regulator receiver protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.929 |
guaB | tgt | Teth39_1720 | Teth39_1017 | Response regulator receiver protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.425 |
queA | ABY95087.1 | Teth39_1016 | Teth39_1437 | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | PFAM: protein of unknown function DUF988. | 0.520 |