| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amb0590 | nadD | amb0590 | amb4083 | Phosphoribosylpyrophosphate synthetase. | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.400 |
| amb0590 | proB | amb0590 | amb4080 | Phosphoribosylpyrophosphate synthetase. | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.604 |
| amb0590 | ribB | amb0590 | amb2344 | Phosphoribosylpyrophosphate synthetase. | Riboflavin biosynthesis protein ribA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.573 |
| amb0590 | rplU | amb0590 | amb4077 | Phosphoribosylpyrophosphate synthetase. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.802 |
| amb2507 | proA | amb2507 | amb4082 | Delta 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.941 |
| amb2507 | proB | amb2507 | amb4080 | Delta 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.944 |
| amb2507 | proC | amb2507 | amb0545 | Delta 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.959 |
| amb2507 | ribB | amb2507 | amb2344 | Delta 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Riboflavin biosynthesis protein ribA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.438 |
| amb4081 | nadD | amb4081 | amb4083 | N-acetylmuramoyl-L-alanine amidase. | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.731 |
| amb4081 | obg | amb4081 | amb4079 | N-acetylmuramoyl-L-alanine amidase. | Predicted GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.794 |
| amb4081 | proA | amb4081 | amb4082 | N-acetylmuramoyl-L-alanine amidase. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.740 |
| amb4081 | proB | amb4081 | amb4080 | N-acetylmuramoyl-L-alanine amidase. | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.787 |
| amb4081 | rplU | amb4081 | amb4077 | N-acetylmuramoyl-L-alanine amidase. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.489 |
| amb4081 | rpmA | amb4081 | amb4078 | N-acetylmuramoyl-L-alanine amidase. | Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. | 0.565 |
| nadD | amb0590 | amb4083 | amb0590 | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Phosphoribosylpyrophosphate synthetase. | 0.400 |
| nadD | amb4081 | amb4083 | amb4081 | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | N-acetylmuramoyl-L-alanine amidase. | 0.731 |
| nadD | obg | amb4083 | amb4079 | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Predicted GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.879 |
| nadD | proA | amb4083 | amb4082 | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.909 |
| nadD | proB | amb4083 | amb4080 | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.827 |
| nadD | ribB | amb4083 | amb2344 | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Riboflavin biosynthesis protein ribA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.535 |