node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PNA2_0121 | prf1 | PNA2_0121 | PNA2_0168 | Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.704 |
PNA2_0121 | rtcA | PNA2_0121 | PNA2_0113 | Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | RNA 3'-terminal-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.807 |
PNA2_0121 | rtcB | PNA2_0121 | PNA2_0188 | Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Hypothetical protein; Belongs to the RtcB family. | 0.983 |
PNA2_0635 | rtcA | PNA2_0635 | PNA2_0113 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | RNA 3'-terminal-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.567 |
PNA2_0635 | rtcB | PNA2_0635 | PNA2_0188 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Hypothetical protein; Belongs to the RtcB family. | 0.726 |
PNA2_0714 | rtcB | PNA2_0714 | PNA2_0188 | Hypothetical protein. | Hypothetical protein; Belongs to the RtcB family. | 0.615 |
PNA2_1690 | rtcB | PNA2_1690 | PNA2_0188 | Ferredoxin 3. | Hypothetical protein; Belongs to the RtcB family. | 0.586 |
eif1a | eif2a | PNA2_0156 | PNA2_1638 | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Translation initiation factor IF-2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. | 0.999 |
eif1a | prf1 | PNA2_0156 | PNA2_0168 | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.719 |
eif1a | rtcB | PNA2_0156 | PNA2_0188 | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Hypothetical protein; Belongs to the RtcB family. | 0.684 |
eif2a | eif1a | PNA2_1638 | PNA2_0156 | Translation initiation factor IF-2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 0.999 |
eif2a | prf1 | PNA2_1638 | PNA2_0168 | Translation initiation factor IF-2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.782 |
eif2a | rtcB | PNA2_1638 | PNA2_0188 | Translation initiation factor IF-2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. | Hypothetical protein; Belongs to the RtcB family. | 0.668 |
kptA | rtcA | PNA2_0695 | PNA2_0113 | RNA 2'-phosphotransferase-like protein; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. | RNA 3'-terminal-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.426 |
kptA | rtcB | PNA2_0695 | PNA2_0188 | RNA 2'-phosphotransferase-like protein; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. | Hypothetical protein; Belongs to the RtcB family. | 0.674 |
prf1 | PNA2_0121 | PNA2_0168 | PNA2_0121 | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.704 |
prf1 | eif1a | PNA2_0168 | PNA2_0156 | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 0.719 |
prf1 | eif2a | PNA2_0168 | PNA2_1638 | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | Translation initiation factor IF-2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. | 0.782 |
prf1 | rtcB | PNA2_0168 | PNA2_0188 | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | Hypothetical protein; Belongs to the RtcB family. | 0.648 |
rnp4 | rtcB | PNA2_0186 | PNA2_0188 | Ribonuclease P protein component 4; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. | Hypothetical protein; Belongs to the RtcB family. | 0.690 |