node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PNA2_0284 | PNA2_1513 | PNA2_0284 | PNA2_1513 | Adenine phosphoribosyltransferase. | Hypothetical protein. | 0.500 |
PNA2_0284 | PNA2_1805 | PNA2_0284 | PNA2_1805 | Adenine phosphoribosyltransferase. | Asparagine synthetase, putative. | 0.730 |
PNA2_0284 | guaAA | PNA2_0284 | PNA2_1921 | Adenine phosphoribosyltransferase. | GMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. | 0.628 |
PNA2_0284 | guaAB | PNA2_0284 | PNA2_1923 | Adenine phosphoribosyltransferase. | GMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. | 0.865 |
PNA2_0284 | guaB | PNA2_0284 | PNA2_0926 | Adenine phosphoribosyltransferase. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.575 |
PNA2_0284 | pyrG | PNA2_0284 | PNA2_0395 | Adenine phosphoribosyltransferase. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.629 |
PNA2_0889 | PNA2_1805 | PNA2_0889 | PNA2_1805 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Asparagine synthetase, putative. | 0.593 |
PNA2_0889 | guaAA | PNA2_0889 | PNA2_1921 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. | 0.934 |
PNA2_0889 | guaAB | PNA2_0889 | PNA2_1923 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. | 0.968 |
PNA2_0889 | guaB | PNA2_0889 | PNA2_0926 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.942 |
PNA2_0889 | valS | PNA2_0889 | PNA2_0932 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.535 |
PNA2_1513 | PNA2_0284 | PNA2_1513 | PNA2_0284 | Hypothetical protein. | Adenine phosphoribosyltransferase. | 0.500 |
PNA2_1513 | argS | PNA2_1513 | PNA2_0063 | Hypothetical protein. | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.602 |
PNA2_1513 | guaAA | PNA2_1513 | PNA2_1921 | Hypothetical protein. | GMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. | 0.418 |
PNA2_1513 | guaAB | PNA2_1513 | PNA2_1923 | Hypothetical protein. | GMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. | 0.857 |
PNA2_1513 | guaB | PNA2_1513 | PNA2_0926 | Hypothetical protein. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.444 |
PNA2_1513 | pyrG | PNA2_1513 | PNA2_0395 | Hypothetical protein. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.637 |
PNA2_1513 | valS | PNA2_1513 | PNA2_0932 | Hypothetical protein. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.764 |
PNA2_1805 | PNA2_0284 | PNA2_1805 | PNA2_0284 | Asparagine synthetase, putative. | Adenine phosphoribosyltransferase. | 0.730 |
PNA2_1805 | PNA2_0889 | PNA2_1805 | PNA2_0889 | Asparagine synthetase, putative. | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.593 |