node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SG0404 | adk | SG0404 | SG0693 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.436 |
SG0404 | cysG | SG0404 | SG0520 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.503 |
SG0404 | gltA | SG0404 | SG0871 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Citrate synthase; Belongs to the citrate synthase family. | 0.472 |
SG0404 | hemL | SG0404 | SG0500 | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Glutamate-1-semialdehyde aminotransferase. | 0.545 |
adk | SG0404 | SG0693 | SG0404 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.436 |
adk | hemL | SG0693 | SG0500 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Glutamate-1-semialdehyde aminotransferase. | 0.536 |
cysG | SG0404 | SG0520 | SG0404 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.503 |
cysG | hemA | SG0520 | SG1877 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.775 |
cysG | hemB | SG0520 | SG1529 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.884 |
cysG | hemC | SG0520 | SG2366 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.993 |
cysG | hemE | SG0520 | SG0138 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.950 |
cysG | hemL | SG0520 | SG0500 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamate-1-semialdehyde aminotransferase. | 0.748 |
ftsK | hemL | SG1108 | SG0500 | Cell division protein. | Glutamate-1-semialdehyde aminotransferase. | 0.621 |
gltA | SG0404 | SG0871 | SG0404 | Citrate synthase; Belongs to the citrate synthase family. | Aspartokinase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.472 |
gltA | hemL | SG0871 | SG0500 | Citrate synthase; Belongs to the citrate synthase family. | Glutamate-1-semialdehyde aminotransferase. | 0.528 |
gltA | ptsG_1 | SG0871 | SG0859 | Citrate synthase; Belongs to the citrate synthase family. | PTS system N-acetylglucosamine-specific IIABC component. | 0.422 |
hemA | cysG | SG1877 | SG0520 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.775 |
hemA | hemB | SG1877 | SG1529 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.866 |
hemA | hemC | SG1877 | SG2366 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
hemA | hemE | SG1877 | SG0138 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.642 |