node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SG2368 | cysG | SG2368 | SG0520 | Uroporphyrinogen III methylase. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.913 |
SG2368 | hemC | SG2368 | SG2366 | Uroporphyrinogen III methylase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.860 |
SG2368 | hemD | SG2368 | SG2367 | Uroporphyrinogen III methylase. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.989 |
SG2368 | hemE | SG2368 | SG0138 | Uroporphyrinogen III methylase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.905 |
cysC | cysD | SG0523 | SG0521 | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. | ATP-sulfurylase subunit 2. | 0.999 |
cysC | cysG | SG0523 | SG0520 | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.988 |
cysC | cysH | SG0523 | SG0518 | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. | 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.999 |
cysC | cysI | SG0523 | SG0517 | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.959 |
cysC | cysN | SG0523 | SG0522 | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. | ATP-sulfurylase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.999 |
cysD | cysC | SG0521 | SG0523 | ATP-sulfurylase subunit 2. | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.999 |
cysD | cysG | SG0521 | SG0520 | ATP-sulfurylase subunit 2. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.984 |
cysD | cysH | SG0521 | SG0518 | ATP-sulfurylase subunit 2. | 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.981 |
cysD | cysI | SG0521 | SG0517 | ATP-sulfurylase subunit 2. | Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.955 |
cysD | cysN | SG0521 | SG0522 | ATP-sulfurylase subunit 2. | ATP-sulfurylase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.999 |
cysG | SG2368 | SG0520 | SG2368 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen III methylase. | 0.913 |
cysG | cysC | SG0520 | SG0523 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.988 |
cysG | cysD | SG0520 | SG0521 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | ATP-sulfurylase subunit 2. | 0.984 |
cysG | cysH | SG0520 | SG0518 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.969 |
cysG | cysI | SG0520 | SG0517 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.978 |
cysG | cysN | SG0520 | SG0522 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | ATP-sulfurylase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.883 |