STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lpoBConserved hypothetical protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). (195 aa)    
Predicted Functional Partners:
SG1069
Conserved hypothetical protein.
 
  
 0.955
mrcB
Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
  
 
 
 0.900
thiK
Conserved hypothetical protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate.
 
  
 0.839
SG1068
Conserved hypothetical protein.
  
  
 0.793
ftsN
Cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
  
   
 0.781
ompC
Outer membrane protein.
  
     0.773
SG1489
Conserved hypothetical protein.
  
     0.770
ompF
Outer membrane protein F; Belongs to the Gram-negative porin family.
  
     0.769
holD
DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.
  
     0.765
atpI
ATP synthase subunit I.
  
     0.762
Your Current Organism:
Sodalis glossinidius
NCBI taxonomy Id: 343509
Other names: S. glossinidius str. 'morsitans', Sodalis glossinidius str. 'morsitans'
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.