STRINGSTRING
purH protein (Rhizobium etli CFN42) - STRING interaction network
"purH" - Bifunctional purine biosynthesis protein PurH in Rhizobium etli CFN42
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purHBifunctional purine biosynthesis protein PurH; Putative location-bacterial inner membrane Psort-Score- 0.1383; similar to purH (SMc04088) [Sinorhizobium meliloti]; Similar to entrez-protein-Q92KX6; Protein involved in transferase activity, hydrolase activity, catalytic activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, IMP cyclohydrolase activity, metabolism and purine nucleotide biosynthesis (538 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (205 aa)
  0.999
purD
Phosphoribosylamine--glycine ligase; Similar to purD (SMc00993) [Sinorhizobium meliloti]; Similar to entrez-protein-Q92RL0; Putative location-bacterial inner membrane Psort-Score- 0.1044; Protein involved in ligase activity, phosphoribosylamine-glycine ligase activity, purine nucleotide biosynthesis and purine base biosynthesis; Belongs to the GARS family (427 aa)
 
 
  0.998
purB
Adenylosuccinate lyase; Similar to purB (SMc00508) [Sinorhizobium meliloti] and AGR_C_3377p [Agrobacterium tumefaciens]; Similar to swissprot-Q92PJ3; Putative location-bacterial cytoplasm Psort-Score- 0.1333; Protein involved in catalytic activity, lyase activity, adenylosuccinate lyase activity and purine ribonucleotide biosynthesis (435 aa)
   
  0.997
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (432 aa)
 
  0.994
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (432 aa)
   
  0.994
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (494 aa)
 
  0.986
folDch
Bifunctional protein FolD 1; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (299 aa)
 
  0.985
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Similar to PurM [Rhizobium leguminosarum] and purM (SMc00615) [Sinorhizobium meliloti]; Similar to entrez-protein-CAB46525.1; Putative location-bacterial inner membrane Psort-Score- 0.1341; Protein involved in catalytic activity, phosphoribosylformylglycinamidine cyclo-ligase activity and `de novo` IMP biosynthesis (357 aa)
 
 
  0.985
purL
Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought t [...] (743 aa)
 
 
  0.983
purC1
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to purC (AGR_C_3382p) [Agrobacterium tumefaciens]; Similar to entrez-protein-Q8UEB7; Putative location-bacterial cytoplasm Psort-Score- 0.2032; Protein involved in ligase activity, phosphoribosylaminoimidazolesuccinocarboxamide synthase activity and purine nucleotide biosynthesis; Belongs to the SAICAR synthetase family (254 aa)
 
 
  0.980
Your Current Organism:
Rhizobium etli CFN42
NCBI taxonomy Id: 347834
Other names: R. etli CFN 42, Rhizobium etli CFN 42, Rhizobium etli CFN42, Rhizobium etli str. CFN 42, Rhizobium etli strain CFN 42
Server load: low (15%) [HD]