STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (304 aa)    
Predicted Functional Partners:
citZ
Citrate synthase; Unknown EC_number=2.3.3.16.
  
 0.997
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.989
icd
Isocitrate dehydrogenase (NADP).
  
 
 0.977
sdhB
Succinate dehydrogenase subunit B; Deleted EC_number 1.3.99.1.
  
 
 0.942
sucD
succinate--CoA ligase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.942
maeB1
Malate dehydrogenase (oxaloacetate-decarboxylating).
  
 0.940
maeB2
Malate dehydrogenase (oxaloacetate-decarboxylating).
  
 0.940
aceB
Malate synthase.
  
 
 0.940
gap
Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating).
 
 
 0.935
aspC2
Pyridoxal phosphate-dependent aminotransferase.
  
 0.935
Your Current Organism:
Natronomonas pharaonis
NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160
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