node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NP_4530A | hemQ | NP_4530A | NP_2262A | DUF1405 family protein. | Heme-binding protein HemQ; In the N-terminal section; belongs to the UPF0447 family. | 0.533 |
NP_4530A | pcrB | NP_4530A | NP_1224A | DUF1405 family protein. | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.695 |
NP_4530A | yvoF | NP_4530A | NP_4198A | DUF1405 family protein. | O-acetyltransferase (homolog to galactoside O-acetyltransferase). | 0.764 |
ctaA | hemQ | NP_1770A | NP_2262A | Heme A synthase. | Heme-binding protein HemQ; In the N-terminal section; belongs to the UPF0447 family. | 0.476 |
ctaA | pcrB | NP_1770A | NP_1224A | Heme A synthase. | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.462 |
gatB | pcrB | NP_1220A | NP_1224A | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.636 |
gatB | topA | NP_1220A | NP_1222A | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.727 |
gldA | pcrB | NP_4492A | NP_1224A | Glycerol-1-phosphate dehydrogenase (NAD(P)); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.952 |
gldA | ubiA2 | NP_4492A | NP_4470A | Glycerol-1-phosphate dehydrogenase (NAD(P)); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.542 |
hemQ | NP_4530A | NP_2262A | NP_4530A | Heme-binding protein HemQ; In the N-terminal section; belongs to the UPF0447 family. | DUF1405 family protein. | 0.533 |
hemQ | ctaA | NP_2262A | NP_1770A | Heme-binding protein HemQ; In the N-terminal section; belongs to the UPF0447 family. | Heme A synthase. | 0.476 |
hemQ | pcrB | NP_2262A | NP_1224A | Heme-binding protein HemQ; In the N-terminal section; belongs to the UPF0447 family. | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.601 |
mmcA2 | pcrB | NP_1226A | NP_1224A | methylmalonyl-CoA mutase subunit A. | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.516 |
pcrB | NP_4530A | NP_1224A | NP_4530A | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | DUF1405 family protein. | 0.695 |
pcrB | ctaA | NP_1224A | NP_1770A | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | Heme A synthase. | 0.462 |
pcrB | gatB | NP_1224A | NP_1220A | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. | 0.636 |
pcrB | gldA | NP_1224A | NP_4492A | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | Glycerol-1-phosphate dehydrogenase (NAD(P)); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. | 0.952 |
pcrB | hemQ | NP_1224A | NP_2262A | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | Heme-binding protein HemQ; In the N-terminal section; belongs to the UPF0447 family. | 0.601 |
pcrB | mmcA2 | NP_1224A | NP_1226A | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | methylmalonyl-CoA mutase subunit A. | 0.516 |
pcrB | topA | NP_1224A | NP_1222A | (S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.741 |