node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP69132.1 | ABP70352.1 | Rsph17025_0222 | Rsph17025_1458 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | 0.829 |
ABP69132.1 | ABP71898.1 | Rsph17025_0222 | Rsph17025_3012 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.978 |
ABP69132.1 | carA | Rsph17025_0222 | Rsph17025_0661 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; Belongs to the CarA family. | 0.958 |
ABP69132.1 | carB | Rsph17025_0222 | Rsph17025_0361 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; Belongs to the CarB family. | 0.960 |
ABP69132.1 | guaA | Rsph17025_0222 | Rsph17025_1867 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.653 |
ABP69132.1 | pyrB | Rsph17025_0222 | Rsph17025_0223 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
ABP69132.1 | pyrC | Rsph17025_0222 | Rsph17025_0325 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.928 |
ABP69132.1 | pyrE | Rsph17025_0222 | Rsph17025_0324 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.909 |
ABP69229.1 | guaA | Rsph17025_0323 | Rsph17025_1867 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.499 |
ABP69229.1 | purF | Rsph17025_0323 | Rsph17025_1062 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.422 |
ABP69229.1 | pyrC | Rsph17025_0323 | Rsph17025_0325 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.565 |
ABP69229.1 | pyrE | Rsph17025_0323 | Rsph17025_0324 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.682 |
ABP70352.1 | ABP69132.1 | Rsph17025_1458 | Rsph17025_0222 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. | 0.829 |
ABP70352.1 | carA | Rsph17025_1458 | Rsph17025_0661 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; Belongs to the CarA family. | 0.910 |
ABP70352.1 | carB | Rsph17025_1458 | Rsph17025_0361 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; Belongs to the CarB family. | 0.918 |
ABP70352.1 | guaA | Rsph17025_1458 | Rsph17025_1867 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.671 |
ABP70352.1 | purF | Rsph17025_1458 | Rsph17025_1062 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.477 |
ABP70352.1 | pyrB | Rsph17025_1458 | Rsph17025_0223 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.913 |
ABP70352.1 | pyrC | Rsph17025_1458 | Rsph17025_0325 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.904 |
ABP70352.1 | pyrE | Rsph17025_1458 | Rsph17025_0324 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.942 |