node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP69615.1 | ABP69751.1 | Rsph17025_0709 | Rsph17025_0847 | PFAM: homocysteine S-methyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.923 |
ABP69615.1 | ABP69929.1 | Rsph17025_0709 | Rsph17025_1028 | PFAM: homocysteine S-methyltransferase. | PFAM: dihydropteroate synthase, DHPS. | 0.999 |
ABP69615.1 | ABP71188.1 | Rsph17025_0709 | Rsph17025_2299 | PFAM: homocysteine S-methyltransferase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel. | 0.936 |
ABP69615.1 | fhs | Rsph17025_0709 | Rsph17025_0569 | PFAM: homocysteine S-methyltransferase. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.931 |
ABP69615.1 | glyA | Rsph17025_0709 | Rsph17025_0354 | PFAM: homocysteine S-methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
ABP69615.1 | purH | Rsph17025_0709 | Rsph17025_2928 | PFAM: homocysteine S-methyltransferase. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.913 |
ABP69615.1 | purN | Rsph17025_0709 | Rsph17025_3067 | PFAM: homocysteine S-methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.921 |
ABP69751.1 | ABP69615.1 | Rsph17025_0847 | Rsph17025_0709 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: homocysteine S-methyltransferase. | 0.923 |
ABP69751.1 | ABP69929.1 | Rsph17025_0847 | Rsph17025_1028 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: dihydropteroate synthase, DHPS. | 0.900 |
ABP69751.1 | ABP71188.1 | Rsph17025_0847 | Rsph17025_2299 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel. | 0.923 |
ABP69751.1 | fhs | Rsph17025_0847 | Rsph17025_0569 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.945 |
ABP69751.1 | folD | Rsph17025_0847 | Rsph17025_0571 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.461 |
ABP69751.1 | glyA | Rsph17025_0847 | Rsph17025_0354 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
ABP69751.1 | purH | Rsph17025_0847 | Rsph17025_2928 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.932 |
ABP69751.1 | purN | Rsph17025_0847 | Rsph17025_3067 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
ABP69929.1 | ABP69615.1 | Rsph17025_1028 | Rsph17025_0709 | PFAM: dihydropteroate synthase, DHPS. | PFAM: homocysteine S-methyltransferase. | 0.999 |
ABP69929.1 | ABP69751.1 | Rsph17025_1028 | Rsph17025_0847 | PFAM: dihydropteroate synthase, DHPS. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
ABP69929.1 | ABP71188.1 | Rsph17025_1028 | Rsph17025_2299 | PFAM: dihydropteroate synthase, DHPS. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel. | 0.925 |
ABP69929.1 | fhs | Rsph17025_1028 | Rsph17025_0569 | PFAM: dihydropteroate synthase, DHPS. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.946 |
ABP69929.1 | folD | Rsph17025_1028 | Rsph17025_0571 | PFAM: dihydropteroate synthase, DHPS. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.490 |