node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP69297.1 | hisA | Rsph17025_0391 | Rsph17025_2251 | PFAM: aminotransferase, class I and II. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.896 |
ABP69297.1 | hisB | Rsph17025_0391 | Rsph17025_2249 | PFAM: aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.911 |
ABP69297.1 | hisD | Rsph17025_0391 | Rsph17025_0593 | PFAM: aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.910 |
ABP69297.1 | hisE | Rsph17025_0391 | Rsph17025_2253 | PFAM: aminotransferase, class I and II. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.907 |
ABP69297.1 | hisF | Rsph17025_0391 | Rsph17025_2252 | PFAM: aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.908 |
ABP69297.1 | hisH | Rsph17025_0391 | Rsph17025_2250 | PFAM: aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.914 |
ABP69297.1 | hisI | Rsph17025_0391 | Rsph17025_1163 | PFAM: aminotransferase, class I and II. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.912 |
ABP71967.1 | hisA | Rsph17025_3083 | Rsph17025_2251 | PFAM: aminotransferase, class I and II. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.924 |
ABP71967.1 | hisB | Rsph17025_3083 | Rsph17025_2249 | PFAM: aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.996 |
ABP71967.1 | hisC | Rsph17025_3083 | Rsph17025_2213 | PFAM: aminotransferase, class I and II. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.924 |
ABP71967.1 | hisD | Rsph17025_3083 | Rsph17025_0593 | PFAM: aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.978 |
ABP71967.1 | hisE | Rsph17025_3083 | Rsph17025_2253 | PFAM: aminotransferase, class I and II. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.912 |
ABP71967.1 | hisF | Rsph17025_3083 | Rsph17025_2252 | PFAM: aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.934 |
ABP71967.1 | hisH | Rsph17025_3083 | Rsph17025_2250 | PFAM: aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.948 |
ABP71967.1 | hisI | Rsph17025_3083 | Rsph17025_1163 | PFAM: aminotransferase, class I and II. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.945 |
hisA | ABP69297.1 | Rsph17025_2251 | Rsph17025_0391 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: aminotransferase, class I and II. | 0.896 |
hisA | ABP71967.1 | Rsph17025_2251 | Rsph17025_3083 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: aminotransferase, class I and II. | 0.924 |
hisA | hisB | Rsph17025_2251 | Rsph17025_2249 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: imidazoleglycerol-phosphate dehydratase. | 0.994 |
hisA | hisC | Rsph17025_2251 | Rsph17025_2213 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.934 |
hisA | hisD | Rsph17025_2251 | Rsph17025_0593 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.994 |