node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hhal_1026 | Hhal_1027 | Hhal_1026 | Hhal_1027 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | 0.988 |
Hhal_1026 | Hhal_1028 | Hhal_1026 | Hhal_1028 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: HemY domain protein; Tetratricopeptide TPR_4; KEGG: aeh:Mlg_2667 HemY domain protein. | 0.873 |
Hhal_1026 | Hhal_1051 | Hhal_1026 | Hhal_1051 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aeh:Mlg_2828 porphobilinogen synthase; Belongs to the ALAD family. | 0.915 |
Hhal_1026 | cysG1 | Hhal_1026 | Hhal_1343 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.994 |
Hhal_1026 | cysG2 | Hhal_1026 | Hhal_1933 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.996 |
Hhal_1026 | hemA | Hhal_1026 | Hhal_0993 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.781 |
Hhal_1026 | hemC | Hhal_1026 | Hhal_1025 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Hhal_1026 | hemE | Hhal_1026 | Hhal_1058 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.940 |
Hhal_1026 | hemL | Hhal_1026 | Hhal_2011 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: aeh:Mlg_0806 glutamate-1-semialdehyde-2,1-aminomutase. | 0.599 |
Hhal_1027 | Hhal_1026 | Hhal_1027 | Hhal_1026 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.988 |
Hhal_1027 | Hhal_1028 | Hhal_1027 | Hhal_1028 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | PFAM: HemY domain protein; Tetratricopeptide TPR_4; KEGG: aeh:Mlg_2667 HemY domain protein. | 0.982 |
Hhal_1027 | cysG1 | Hhal_1027 | Hhal_1343 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
Hhal_1027 | cysG2 | Hhal_1027 | Hhal_1933 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
Hhal_1027 | hemC | Hhal_1027 | Hhal_1025 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.866 |
Hhal_1027 | hemE | Hhal_1027 | Hhal_1058 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.903 |
Hhal_1028 | Hhal_1026 | Hhal_1028 | Hhal_1026 | PFAM: HemY domain protein; Tetratricopeptide TPR_4; KEGG: aeh:Mlg_2667 HemY domain protein. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.873 |
Hhal_1028 | Hhal_1027 | Hhal_1028 | Hhal_1027 | PFAM: HemY domain protein; Tetratricopeptide TPR_4; KEGG: aeh:Mlg_2667 HemY domain protein. | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | 0.982 |
Hhal_1028 | hemC | Hhal_1028 | Hhal_1025 | PFAM: HemY domain protein; Tetratricopeptide TPR_4; KEGG: aeh:Mlg_2667 HemY domain protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.854 |
Hhal_1051 | Hhal_1026 | Hhal_1051 | Hhal_1026 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aeh:Mlg_2828 porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.915 |
Hhal_1051 | Hhal_1621 | Hhal_1051 | Hhal_1621 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aeh:Mlg_2828 porphobilinogen synthase; Belongs to the ALAD family. | Protoporphyrin IX magnesium-chelatase; PFAM: von Willebrand factor, type A; KEGG: rru:Rru_A0486 von Willebrand factor, type A. | 0.496 |