node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hhal_0220 | Hhal_0402 | Hhal_0220 | Hhal_0402 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.917 |
Hhal_0220 | Hhal_1040 | Hhal_0220 | Hhal_1040 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.929 |
Hhal_0220 | eno | Hhal_0220 | Hhal_1437 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | 0.919 |
Hhal_0220 | pckG | Hhal_0220 | Hhal_1673 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.909 |
Hhal_0220 | ppc | Hhal_0220 | Hhal_2291 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.929 |
Hhal_0402 | Hhal_0220 | Hhal_0402 | Hhal_0220 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.917 |
Hhal_0402 | Hhal_1040 | Hhal_0402 | Hhal_1040 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.948 |
Hhal_0402 | Hhal_2251 | Hhal_0402 | Hhal_2251 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | KEGG: aeh:Mlg_2752 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. | 0.929 |
Hhal_0402 | glcB | Hhal_0402 | Hhal_2247 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.869 |
Hhal_0402 | gpmA | Hhal_0402 | Hhal_1264 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.603 |
Hhal_0402 | mdh | Hhal_0402 | Hhal_0830 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.940 |
Hhal_0402 | pckG | Hhal_0402 | Hhal_1673 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.932 |
Hhal_0402 | ppc | Hhal_0402 | Hhal_2291 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.929 |
Hhal_1040 | Hhal_0220 | Hhal_1040 | Hhal_0220 | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.929 |
Hhal_1040 | Hhal_0402 | Hhal_1040 | Hhal_0402 | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.948 |
Hhal_1040 | eno | Hhal_1040 | Hhal_1437 | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | 0.992 |
Hhal_1040 | gpmA | Hhal_1040 | Hhal_1264 | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.918 |
Hhal_1040 | mdh | Hhal_1040 | Hhal_0830 | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.744 |
Hhal_1040 | pckG | Hhal_1040 | Hhal_1673 | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.930 |
Hhal_1040 | pgk | Hhal_1040 | Hhal_1041 | PFAM: pyruvate kinase; KEGG: aeh:Mlg_2843 pyruvate kinase; Belongs to the pyruvate kinase family. | PFAM: phosphoglycerate kinase; KEGG: aeh:Mlg_2842 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. | 0.977 |