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addA protein (Desulfotomaculum reducens) - STRING interaction network
"addA" - ATP-dependent helicase/nuclease subunit A in Desulfotomaculum reducens
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second shell of interactors
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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addAATP-dependent helicase/nuclease subunit A; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3’ -> 5’ nuclease activities; Belongs to the helicase family. AddA subfamily (1244 aa)    
Predicted Functional Partners:
addB
ATP-dependent helicase/deoxyribonuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5’ -> 3’ nuclease activity (1155 aa)
 
 
  0.996
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (883 aa)
   
   
  0.781
Dred_1188
KEGG- sar-SAR1543 hypothetical protein (397 aa)
   
 
  0.693
Dred_2460
PFAM- protein of unknown function DUF633; KEGG- chy-CHY_0459 hypothetical protein (234 aa)
 
          0.672
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination (256 aa)
   
   
  0.641
Dred_0731
Exonuclease RecJ; TIGRFAM- single-stranded-DNA-specific exonuclease RecJ; PFAM- phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1; KEGG- chy-CHY_2224 single-stranded DNA-specific exonuclease RecJ (885 aa)
     
   
  0.638
recX
Regulatory protein RecX; Modulates RecA activity (210 aa)
         
  0.627
ruvB
Holliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (344 aa)
   
   
  0.626
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (347 aa)
         
  0.625
ruvA
Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (199 aa)
         
  0.622
Your Current Organism:
Desulfotomaculum reducens
NCBI taxonomy Id: 349161
Other names: D. reducens MI-1, Desulfotomaculum reducens, Desulfotomaculum reducens MI-1, Desulfotomaculum reducens str. MI-1, Desulfotomaculum reducens strain MI-1
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