node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dred_0914 | polA | Dred_0914 | Dred_1599 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.721 |
Dred_0914 | rnhA | Dred_0914 | Dred_2456 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.695 |
Dred_0914 | rnhB | Dred_0914 | Dred_2047 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.924 |
Dred_2145 | polA | Dred_2145 | Dred_1599 | KEGG: ava:Ava_4779 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.777 |
Dred_2145 | rnhA | Dred_2145 | Dred_2456 | KEGG: ava:Ava_4779 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.665 |
Dred_2145 | topA | Dred_2145 | Dred_1984 | KEGG: ava:Ava_4779 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.448 |
Dred_2145 | topB | Dred_2145 | Dred_3223 | KEGG: ava:Ava_4779 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.448 |
Dred_2458 | Dred_2459 | Dred_2458 | Dred_2459 | PFAM: protein of unknown function DUF164; KEGG: cac:CAC1304 uncharacterized conserved protein, predicted metal-binding. | PFAM: protein of unknown function DUF34; KEGG: mta:Moth_0626 protein of unknown function DUF34; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. | 0.878 |
Dred_2458 | rnhA | Dred_2458 | Dred_2456 | PFAM: protein of unknown function DUF164; KEGG: cac:CAC1304 uncharacterized conserved protein, predicted metal-binding. | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.686 |
Dred_2459 | Dred_2458 | Dred_2459 | Dred_2458 | PFAM: protein of unknown function DUF34; KEGG: mta:Moth_0626 protein of unknown function DUF34; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. | PFAM: protein of unknown function DUF164; KEGG: cac:CAC1304 uncharacterized conserved protein, predicted metal-binding. | 0.878 |
Dred_2459 | polA | Dred_2459 | Dred_1599 | PFAM: protein of unknown function DUF34; KEGG: mta:Moth_0626 protein of unknown function DUF34; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.537 |
Dred_2459 | rnhA | Dred_2459 | Dred_2456 | PFAM: protein of unknown function DUF34; KEGG: mta:Moth_0626 protein of unknown function DUF34; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.715 |
deoC | polA | Dred_1129 | Dred_1599 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.495 |
deoC | rnhA | Dred_1129 | Dred_2456 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.851 |
nadD | polA | Dred_2519 | Dred_1599 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.411 |
nadD | rnhA | Dred_2519 | Dred_2456 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.645 |
polA | Dred_0914 | Dred_1599 | Dred_0914 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.721 |
polA | Dred_2145 | Dred_1599 | Dred_2145 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | KEGG: ava:Ava_4779 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. | 0.777 |
polA | Dred_2459 | Dred_1599 | Dred_2459 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | PFAM: protein of unknown function DUF34; KEGG: mta:Moth_0626 protein of unknown function DUF34; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. | 0.537 |
polA | deoC | Dred_1599 | Dred_1129 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.495 |