node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dred_0180 | Dred_2498 | Dred_0180 | Dred_2498 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | 0.798 |
Dred_0180 | clpX | Dred_0180 | Dred_2561 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.619 |
Dred_0180 | dnaJ | Dred_0180 | Dred_2495 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.952 |
Dred_0180 | groL | Dred_0180 | Dred_2873 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.798 |
Dred_0180 | grpE | Dred_0180 | Dred_2497 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.908 |
Dred_0180 | hslU | Dred_0180 | Dred_1980 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.790 |
Dred_0180 | hslV | Dred_0180 | Dred_1981 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | ATP dependent peptidase CodWX, CodW component, Threonine peptidase, MEROPS family T01B; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.673 |
Dred_0180 | htpG | Dred_0180 | Dred_1472 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.908 |
Dred_0180 | lon | Dred_0180 | Dred_2559 | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | ATP-dependent proteinase, Serine peptidase, MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.862 |
Dred_2498 | Dred_0180 | Dred_2498 | Dred_0180 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | 0.798 |
Dred_2498 | clpX | Dred_2498 | Dred_2561 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.502 |
Dred_2498 | dnaJ | Dred_2498 | Dred_2495 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.965 |
Dred_2498 | grpE | Dred_2498 | Dred_2497 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.987 |
Dred_2498 | hslU | Dred_2498 | Dred_1980 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.792 |
Dred_2498 | hslV | Dred_2498 | Dred_1981 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | ATP dependent peptidase CodWX, CodW component, Threonine peptidase, MEROPS family T01B; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.799 |
Dred_2498 | htpG | Dred_2498 | Dred_1472 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.903 |
Dred_2498 | lon | Dred_2498 | Dred_2559 | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | ATP-dependent proteinase, Serine peptidase, MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.805 |
clpX | Dred_0180 | Dred_2561 | Dred_0180 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2348 negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. | 0.619 |
clpX | Dred_2498 | Dred_2561 | Dred_2498 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | PFAM: chaperonin Cpn60/TCP-1; KEGG: chy:CHY_0413 thermosome, alpha subunit. | 0.502 |
clpX | dnaJ | Dred_2561 | Dred_2495 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.462 |