STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtcARNA-3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (337 aa)    
Predicted Functional Partners:
csl4
RNA binding S1 domain protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
 
  0.989
rps4
SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 0.974
rps6e
PFAM: ribosomal protein S6e; KEGG: afu:AF0511 30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 0.973
rps11
SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
    
 0.960
rrp42
Ribosomal RNA-processing protein RRP42; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
  
  0.942
Mthe_0831
rRNA biogenesis protein Nop56/Nop58; PFAM: Pre-mRNA processing ribonucleoprotein, binding region; KEGG: mbu:Mbur_1562 pre-mRNA processing ribonucleoprotein.
  
 
 0.937
rrp4
Ribosomal RNA-processing protein RRP4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
  
  0.932
rrp41
Ribosomal RNA-processing protein RRP41/SKI6; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
  
 0.930
rps3ae
PFAM: ribosomal protein S3Ae; KEGG: mbu:Mbur_2336 ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family.
  
 
  0.918
Mthe_0171
PFAM: KH, type 1, domain protein; SMART: KH domain protein; KEGG: mbu:Mbur_0948 KH type RNA-binding protein.
   
 
 0.916
Your Current Organism:
Methanothrix thermoacetophila
NCBI taxonomy Id: 349307
Other names: M. thermoacetophila PT, Methanosaeta thermophila PT, Methanothrix thermoacetophila PT, Methanothrix thermophila DSM 6194, Methanothrix thermophila PT
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