node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mthe_0160 | Mthe_0162 | Mthe_0160 | Mthe_0162 | Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: mba:Mbar_A0575 molybdenum cofactor biosynthesis protein. | PFAM: ribonuclease H; KEGG: sto:ST0753 hypothetical protein. | 0.778 |
Mthe_0160 | Mthe_0163 | Mthe_0160 | Mthe_0163 | Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: mba:Mbar_A0575 molybdenum cofactor biosynthesis protein. | PFAM: NADPH-dependent FMN reductase; KEGG: mba:Mbar_A1822 iron-sulfur flavoprotein. | 0.779 |
Mthe_0160 | aroC | Mthe_0160 | Mthe_0161 | Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: mba:Mbar_A0575 molybdenum cofactor biosynthesis protein. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.781 |
Mthe_0162 | Mthe_0160 | Mthe_0162 | Mthe_0160 | PFAM: ribonuclease H; KEGG: sto:ST0753 hypothetical protein. | Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: mba:Mbar_A0575 molybdenum cofactor biosynthesis protein. | 0.778 |
Mthe_0162 | Mthe_0163 | Mthe_0162 | Mthe_0163 | PFAM: ribonuclease H; KEGG: sto:ST0753 hypothetical protein. | PFAM: NADPH-dependent FMN reductase; KEGG: mba:Mbar_A1822 iron-sulfur flavoprotein. | 0.778 |
Mthe_0162 | aroC | Mthe_0162 | Mthe_0161 | PFAM: ribonuclease H; KEGG: sto:ST0753 hypothetical protein. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.863 |
Mthe_0163 | Mthe_0160 | Mthe_0163 | Mthe_0160 | PFAM: NADPH-dependent FMN reductase; KEGG: mba:Mbar_A1822 iron-sulfur flavoprotein. | Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: mba:Mbar_A0575 molybdenum cofactor biosynthesis protein. | 0.779 |
Mthe_0163 | Mthe_0162 | Mthe_0163 | Mthe_0162 | PFAM: NADPH-dependent FMN reductase; KEGG: mba:Mbar_A1822 iron-sulfur flavoprotein. | PFAM: ribonuclease H; KEGG: sto:ST0753 hypothetical protein. | 0.778 |
Mthe_0163 | aroC | Mthe_0163 | Mthe_0161 | PFAM: NADPH-dependent FMN reductase; KEGG: mba:Mbar_A1822 iron-sulfur flavoprotein. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.786 |
Mthe_1353 | aroA-3 | Mthe_1353 | Mthe_1029 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.917 |
Mthe_1353 | aroC | Mthe_1353 | Mthe_0161 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.986 |
Mthe_1353 | aroE | Mthe_1353 | Mthe_1501 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.599 |
Mthe_1353 | trpA | Mthe_1353 | Mthe_0192 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.653 |
Mthe_1353 | trpB | Mthe_1353 | Mthe_0193 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.653 |
Mthe_1353 | trpD | Mthe_1353 | Mthe_1539 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.678 |
Mthe_1353 | trpE | Mthe_1353 | Mthe_1541 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] | 0.965 |
aroA-3 | Mthe_1353 | Mthe_1029 | Mthe_1353 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mac:MA1377 chorismate mutase. | 0.917 |
aroA-3 | aroC | Mthe_1029 | Mthe_0161 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.998 |
aroA-3 | aroE | Mthe_1029 | Mthe_1501 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.991 |
aroA-3 | trpA | Mthe_1029 | Mthe_0192 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.714 |