STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdxTPyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (186 aa)    
Predicted Functional Partners:
pdxS
Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
 0.999
Mthe_0364
Ribose-5-phosphate isomerase; KEGG: mba:Mbar_A3172 ribose 5-phosphate epimerase; TIGRFAM: ribose 5-phosphate isomerase; PFAM: Ribose 5-phosphate isomerase.
     
 0.804
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
    
  0.804
Mthe_1258
Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: mth:MTH1590 phosphomannomutase.
     
  0.800
Mthe_0921
Hypothetical protein.
       0.794
Mthe_0701
KEGG: pab:PAB0257 NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
     
 0.532
Mthe_0828
TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mba:Mbar_A3501 hydroxymethylpyrimidine kinase.
     
 0.506
Mthe_1178
Mo-nitrogenase iron protein subunit NifH; PFAM: NifH/frxC-family protein; KEGG: mbu:Mbur_1038 nitrogenase.
     
 0.484
Mthe_0922
PFAM: Radical SAM domain protein; KEGG: sat:SYN_01240 pyruvate formate-lyase activating enzyme.
       0.438
Your Current Organism:
Methanothrix thermoacetophila
NCBI taxonomy Id: 349307
Other names: M. thermoacetophila PT, Methanosaeta thermophila PT, Methanothrix thermoacetophila PT, Methanothrix thermophila DSM 6194, Methanothrix thermophila PT
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