node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mthe_1218 | Mthe_1511 | Mthe_1218 | Mthe_1511 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.999 |
Mthe_1218 | hpt | Mthe_1218 | Mthe_1111 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.984 |
Mthe_1218 | purA | Mthe_1218 | Mthe_1304 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.999 |
Mthe_1218 | purC | Mthe_1218 | Mthe_1509 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: SAICAR synthetase; KEGG: tac:Ta0309 phosphoribosylamidoimidazole-succinocarboxamide synthase. | 0.999 |
Mthe_1218 | purD | Mthe_1218 | Mthe_0248 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; KEGG: afu:AF1157 phosphoribosylamine--glycine ligase (PurD); Belongs to the GARS family. | 0.997 |
Mthe_1218 | purE | Mthe_1218 | Mthe_0014 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.998 |
Mthe_1218 | purF | Mthe_1218 | Mthe_0230 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
Mthe_1218 | purL | Mthe_1218 | Mthe_0099 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.996 |
Mthe_1218 | purM | Mthe_1218 | Mthe_1252 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: mma:MM1416 phosphoribosylaminoimidazole synthetase. | 0.989 |
Mthe_1218 | purQ | Mthe_1218 | Mthe_0098 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.983 |
Mthe_1511 | Mthe_1218 | Mthe_1511 | Mthe_1218 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mac:MA3971 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.999 |
Mthe_1511 | hpt | Mthe_1511 | Mthe_1111 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.982 |
Mthe_1511 | purA | Mthe_1511 | Mthe_1304 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.987 |
Mthe_1511 | purC | Mthe_1511 | Mthe_1509 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | PFAM: SAICAR synthetase; KEGG: tac:Ta0309 phosphoribosylamidoimidazole-succinocarboxamide synthase. | 0.999 |
Mthe_1511 | purD | Mthe_1511 | Mthe_0248 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; KEGG: afu:AF1157 phosphoribosylamine--glycine ligase (PurD); Belongs to the GARS family. | 0.999 |
Mthe_1511 | purE | Mthe_1511 | Mthe_0014 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.998 |
Mthe_1511 | purF | Mthe_1511 | Mthe_0230 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
Mthe_1511 | purL | Mthe_1511 | Mthe_0099 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.999 |
Mthe_1511 | purM | Mthe_1511 | Mthe_1252 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: mma:MM1416 phosphoribosylaminoimidazole synthetase. | 0.999 |
Mthe_1511 | purQ | Mthe_1511 | Mthe_0098 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: mca:MCA1747 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.999 |