node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | glyA | LCK_00614 | LCK_00725 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
fhs | purB | LCK_00614 | LCK_00618 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Adenylosuccinate lyase; COG0015F; TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.638 |
fhs | purC | LCK_00614 | LCK_00604 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; COG0152F; Belongs to the SAICAR synthetase family. | 0.822 |
fhs | purD | LCK_00614 | LCK_00613 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine-glycine ligase; COG0151F; Belongs to the GARS family. | 0.847 |
fhs | purE | LCK_00614 | LCK_00602 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.628 |
fhs | purF | LCK_00614 | LCK_00608 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.798 |
fhs | purH | LCK_00614 | LCK_00611 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein PurH; COG0138F; TIGR00355. | 0.985 |
fhs | purL | LCK_00614 | LCK_00607 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] | 0.786 |
fhs | purM | LCK_00614 | LCK_00609 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole (AIR) synthetase; COG0150F. | 0.566 |
fhs | purN | LCK_00614 | LCK_00610 | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.972 |
glyA | fhs | LCK_00725 | LCK_00614 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | 0.965 |
glyA | purB | LCK_00725 | LCK_00618 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; COG0015F; TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.833 |
glyA | purC | LCK_00725 | LCK_00604 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; COG0152F; Belongs to the SAICAR synthetase family. | 0.710 |
glyA | purD | LCK_00725 | LCK_00613 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylamine-glycine ligase; COG0151F; Belongs to the GARS family. | 0.781 |
glyA | purF | LCK_00725 | LCK_00608 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.755 |
glyA | purH | LCK_00725 | LCK_00611 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional purine biosynthesis protein PurH; COG0138F; TIGR00355. | 0.992 |
glyA | purL | LCK_00725 | LCK_00607 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] | 0.696 |
glyA | purM | LCK_00725 | LCK_00609 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylaminoimidazole (AIR) synthetase; COG0150F. | 0.583 |
glyA | purN | LCK_00725 | LCK_00610 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.963 |
purB | fhs | LCK_00618 | LCK_00614 | Adenylosuccinate lyase; COG0015F; TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formyltetrahydrofolate synthetase; COG2759F; Belongs to the formate--tetrahydrofolate ligase family. | 0.638 |