node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCH_00566 | mutM1 | HCH_00566 | HCH_00567 | Conserved hypothetical protein. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.504 |
HCH_03463 | HCH_06325 | HCH_03463 | HCH_06325 | Lhr-like helicase; COG1201. | Conserved hypothetical protein. | 0.424 |
HCH_03463 | mutM1 | HCH_03463 | HCH_00567 | Lhr-like helicase; COG1201. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.580 |
HCH_03463 | mutM2 | HCH_03463 | HCH_02013 | Lhr-like helicase; COG1201. | Formamidopyrimidine-DNA glycosylase; COG0266; Belongs to the FPG family. | 0.580 |
HCH_03463 | uvrC | HCH_03463 | HCH_04042 | Lhr-like helicase; COG1201. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.476 |
HCH_06325 | HCH_03463 | HCH_06325 | HCH_03463 | Conserved hypothetical protein. | Lhr-like helicase; COG1201. | 0.424 |
HCH_06325 | lhr | HCH_06325 | HCH_04162 | Conserved hypothetical protein. | Lhr-like helicase; COG1201. | 0.424 |
HCH_06325 | mutM1 | HCH_06325 | HCH_00567 | Conserved hypothetical protein. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.560 |
HCH_06325 | mutM2 | HCH_06325 | HCH_02013 | Conserved hypothetical protein. | Formamidopyrimidine-DNA glycosylase; COG0266; Belongs to the FPG family. | 0.560 |
HCH_06325 | polA | HCH_06325 | HCH_06350 | Conserved hypothetical protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.524 |
coaE | mutM1 | HCH_05281 | HCH_00567 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.950 |
coaE | mutM2 | HCH_05281 | HCH_02013 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Formamidopyrimidine-DNA glycosylase; COG0266; Belongs to the FPG family. | 0.725 |
coaE | nth | HCH_05281 | HCH_01887 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.546 |
coaE | polA | HCH_05281 | HCH_06350 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.769 |
lhr | HCH_06325 | HCH_04162 | HCH_06325 | Lhr-like helicase; COG1201. | Conserved hypothetical protein. | 0.424 |
lhr | mutM1 | HCH_04162 | HCH_00567 | Lhr-like helicase; COG1201. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.580 |
lhr | mutM2 | HCH_04162 | HCH_02013 | Lhr-like helicase; COG1201. | Formamidopyrimidine-DNA glycosylase; COG0266; Belongs to the FPG family. | 0.743 |
lhr | uvrC | HCH_04162 | HCH_04042 | Lhr-like helicase; COG1201. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.476 |
mutM1 | HCH_00566 | HCH_00567 | HCH_00566 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Conserved hypothetical protein. | 0.504 |
mutM1 | HCH_03463 | HCH_00567 | HCH_03463 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Lhr-like helicase; COG1201. | 0.580 |