node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCH_00650 | HCH_01004 | HCH_00650 | HCH_01004 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | 0.907 |
HCH_00650 | HCH_04831 | HCH_00650 | HCH_04831 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.984 |
HCH_00650 | HCH_06567 | HCH_00650 | HCH_06567 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.861 |
HCH_00650 | cysG | HCH_00650 | HCH_02450 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Uroporphyrinogen-III methylase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.916 |
HCH_00650 | hemA | HCH_00650 | HCH_01731 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.854 |
HCH_00650 | hemC | HCH_00650 | HCH_00291 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
HCH_00650 | hemE | HCH_00650 | HCH_05963 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.786 |
HCH_00650 | hemL | HCH_00650 | HCH_06248 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAMsMatches:TIGR00713. | 0.988 |
HCH_01004 | HCH_00650 | HCH_01004 | HCH_00650 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | 0.907 |
HCH_01004 | HCH_04831 | HCH_01004 | HCH_04831 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.983 |
HCH_01004 | HCH_06567 | HCH_01004 | HCH_06567 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.842 |
HCH_01004 | cysG | HCH_01004 | HCH_02450 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Uroporphyrinogen-III methylase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.913 |
HCH_01004 | hemA | HCH_01004 | HCH_01731 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.852 |
HCH_01004 | hemC | HCH_01004 | HCH_00291 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
HCH_01004 | hemE | HCH_01004 | HCH_05963 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.794 |
HCH_01004 | hemL | HCH_01004 | HCH_06248 | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | Glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAMsMatches:TIGR00713. | 0.988 |
HCH_04831 | HCH_00650 | HCH_04831 | HCH_00650 | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | 0.984 |
HCH_04831 | HCH_01004 | HCH_04831 | HCH_01004 | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Delta-aminolevulinic acid dehydratase; COG0113; Belongs to the ALAD family. | 0.983 |
HCH_04831 | cysG | HCH_04831 | HCH_02450 | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Uroporphyrinogen-III methylase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.580 |
HCH_04831 | hemA | HCH_04831 | HCH_01731 | Glutamate-1-semialdehyde aminotransferase; COG0001; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.980 |